KCNA10: Potassium Voltage-Gated Channel Subfamily A Member 10
A voltage-gated potassium channel involved in renal and vascular function
Gene Information Card
| Symbol | KCNA10 |
|---|---|
| Full Name | Potassium Voltage-Gated Channel Subfamily A Member 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.3 |
| NCBI Gene ID | 3744 ncbi.nlm.nih.gov/gene/3744 |
| Ensembl ID | ENSG00000143105 |
| UniProt ID | Q16322 |
| OMIM ID | 602923 |
| HGNC ID | 6222 |
| Aliases | Kv1.8, KCN1, HK2 |
Description
KCNA10 encodes a voltage-gated potassium channel (Kv1.8) that is primarily expressed in the kidney and vascular smooth muscle. The channel mediates potassium ion efflux, regulating membrane potential and cellular excitability. It plays a role in renal potassium handling and vascular tone modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | Altered channel activity may affect vascular smooth muscle contraction and renal sodium/potassium balance. | PMID: 10880443 |
| Hypokalemia | Dysregulation of potassium secretion in renal tubules. | PMID: 11744706 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Artery | 8.3 | Medium |
| Heart | 3.1 | Low |
| Brain | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| A549 | 0.3 | Low expression |
| HUVEC | 2.1 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Reduced potassium conductance |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Altered voltage sensitivity |
Mutation functional classification
Loss of Function (LOF)
p.Gly38Arg reduces channel current amplitude.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • voltage-gated potassium channel activity (GO:0005249) | • potassium ion transport (GO:0006813) |
| • plasma membrane (GO:0005886) | • voltage-gated potassium channel complex (GO:0008076) |
Pathways
• Potassium channels (Reactome: R-HSA-1296071)
• Voltage gated potassium channels (KEGG: hsa04010)
Protein Summary
The KCNA10 protein (Kv1.8) is a 528-amino acid voltage-gated potassium channel subunit. It forms homotetrameric or heterotetrameric channels with other Kv1 family members. The channel is activated by membrane depolarization and mediates outward potassium current, contributing to repolarization of excitable cells and regulation of renal potassium secretion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KCNA10 Knockout HEK293 Cell Line | EDJ-KQ5019 | Human | 3744 | Details Get a Quote |
| KCNA10 Knockout HeLa Cell Line | EDJ-KQ53699 | Human | 3744 | Details Get a Quote |
| KCNA10 Knockout A-549 Cell Line | EDJ-KQ62177 | Human | 3744 | Details Get a Quote |
| KCNA10 Knockout HCT 116 Cell Line | EDJ-KQ70663 | Human | 3744 | Details Get a Quote |
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