JDP2: Jun Dimerization Protein 2 - A Key Transcription Factor in Cell Differentiation and Cancer
Comprehensive genomic and proteomic overview of JDP2, a member of the AP-1 family of transcription factors, with roles in development, stress response, and tumor suppression.
Gene Information Card
| Symbol | JDP2 |
|---|---|
| Full Name | Jun dimerization protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 122953 ncbi.nlm.nih.gov/gene/122953 |
| Ensembl ID | ENSG00000140044 |
| UniProt ID | Q8WYK2 |
| OMIM ID | 608376 |
| HGNC ID | 28966 |
| Aliases | JUNDM2, JDP-2, JUNDM2, JDP2_HUMAN |
Description
JDP2 (Jun dimerization protein 2) is a protein-coding gene located on chromosome 14q24.3. It encodes a member of the AP-1 family of transcription factors, which forms homodimers or heterodimers with other Jun, Fos, or ATF proteins. JDP2 functions as a transcriptional repressor or activator, regulating genes involved in cell differentiation, proliferation, apoptosis, and stress response. It plays a critical role in embryonic development, adipogenesis, and osteoclastogenesis. JDP2 is also implicated in cancer, where it can act as a tumor suppressor by modulating chromatin remodeling and gene expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | JDP2 acts as a tumor suppressor by repressing oncogene expression and promoting differentiation; loss of JDP2 expression is associated with increased tumorigenesis. | COSMIC; NCBI Gene; PMID: 21930790 |
| Osteoporosis | JDP2 regulates osteoclast differentiation via AP-1 signaling; altered expression may contribute to bone density disorders. | OMIM; PMID: 17519248 |
| Adipogenesis disorders | JDP2 is involved in adipocyte differentiation; dysregulation may affect fat metabolism and obesity. | UniProt; PMID: 15601869 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Liver | 2.1 | Not detected |
| Kidney | 4.5 | Low |
| Lung | 6.0 | Medium |
| Testis | 8.9 | Medium |
| Spleen | 3.0 | Low |
| Bone marrow | 7.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 6.5 | Cervical cancer cell line |
| K562 | 8.2 | Leukemia cell line |
| A549 | 5.9 | Lung cancer cell line |
| MCF7 | 4.8 | Breast cancer cell line |
| HEK293 | 7.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256C>T (p.Arg86Trp) | Missense | <0.1% | Alters DNA-binding domain; potential loss of transcriptional activity |
| c.487_489del (p.Lys163del) | In-frame deletion | <0.1% | May affect dimerization; functional impact unknown |
| c.1A>G (p.Met1Val) | Start loss | <0.1% | Likely loss of protein expression |
Mutation functional classification
Loss of Function (LOF)
Mutations in the DNA-binding domain (e.g., p.Arg86Trp) or start-loss variants (p.Met1Val) are predicted to reduce or abolish JDP2 transcriptional activity, consistent with a tumor suppressor role.
Gain of Function (GOF)
No gain-of-function mutations have been reported for JDP2 in COSMIC or ClinVar.
Dominant Negative (DN)
Deletion of the dimerization domain (e.g., p.Lys163del) may produce a truncated protein that interferes with wild-type JDP2 or other AP-1 factors, acting in a dominant-negative manner.
View complete mutation data：
Gene Ontology (GO)
Pathways
• AP-1 transcription factor network
• TNF signaling pathway
• IL-17 signaling pathway
• Osteoclast differentiation
• Adipogenesis
Protein Summary
JDP2 is a 163-amino acid protein (UniProt Q8WYK2) that contains a basic leucine zipper (bZIP) domain, mediating DNA binding and dimerization. It forms homodimers or heterodimers with Jun, Fos, or ATF proteins to regulate transcription. JDP2 represses transcription by recruiting histone deacetylases (HDACs) and chromatin remodeling complexes, thereby modulating gene expression in differentiation, stress, and cancer. The protein is predominantly nuclear and expressed in multiple tissues, with highest levels in testis and bone marrow.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| JDP2 Knockout HEK293 Cell Line | EDJ-KQ8167 | Human | 122953 | Details Get a Quote |
| JDP2 Knockout HCT 116 Cell Line | EDJ-KQ34073 | Human | 122953 | Details Get a Quote |
| JDP2 Knockout HeLa Cell Line | EDJ-KQ34074 | Human | 122953 | Details Get a Quote |
| JDP2 Knockout A-549 Cell Line | EDJ-KQ32737 | Human | 122953 | Details Get a Quote |
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