IVNS1ABP Gene - Influenza Virus NS1A Binding Protein
Comprehensive genomic and functional analysis of IVNS1ABP
Gene Information Card
| Symbol | IVNS1ABP |
|---|---|
| Full Name | Influenza Virus NS1A Binding Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 1q42.13 |
| NCBI Gene ID | 10625 ncbi.nlm.nih.gov/gene/10625 |
| Ensembl ID | ENSG00000116679 |
| UniProt ID | Q9Y6Y0 |
| OMIM ID | 609209 |
| HGNC ID | 6140 |
| Aliases | FLJ10385, HSPC068, NS1-BP, NS1BP |
Description
IVNS1ABP (Influenza Virus NS1A Binding Protein) is a protein-coding gene located on chromosome 1q42.13. The encoded protein interacts with the NS1 protein of influenza A virus and is involved in cellular antiviral responses. It also plays a role in mRNA splicing and cytoskeletal organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Influenza A infection | Viral NS1 protein binding modulates host immune response | Experimental evidence from NCBI Gene and UniProt |
| Cancer (various) | Potential role in cell proliferation and splicing regulation | Limited evidence from COSMIC mutation data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Lung | 7.3 | Low |
| Brain | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 12.0 | Moderate expression |
| K562 | 8.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.01% | Unknown functional effect |
| c.567C>T (p.Pro189Leu) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • mRNA splicing (GO:0000398) | • viral process (GO:0016032) |
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) |
Pathways
• Influenza A (KEGG: hsa05164)
• mRNA surveillance pathway (KEGG: hsa03015)
Protein Summary
The IVNS1ABP protein (UniProt Q9Y6Y0) is a 589-amino acid protein that localizes to the nucleus and cytoplasm. It contains a BTB/POZ domain and interacts with influenza A virus NS1 protein, modulating host antiviral responses. It also participates in pre-mRNA splicing and may influence cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IVNS1ABP Knockout HEK293 Cell Line | EDJ-KQ3374 | Human | 10625 | Details Get a Quote |
| IVNS1ABP Knockout A-549 Cell Line | EDJ-KQ25050 | Human | 10625 | Details Get a Quote |
| IVNS1ABP Knockout HCT 116 Cell Line | EDJ-KQ25051 | Human | 10625 | Details Get a Quote |
| IVNS1ABP Knockout HeLa Cell Line | EDJ-KQ25052 | Human | 10625 | Details Get a Quote |
