ITGA1 (Integrin Subunit Alpha 1)
A key collagen receptor involved in cell adhesion, migration, and tissue homeostasis.
Gene Information Card
| Symbol | ITGA1 |
|---|---|
| Full Name | Integrin Subunit Alpha 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q11.2 |
| NCBI Gene ID | 3672 ncbi.nlm.nih.gov/gene/3672 |
| Ensembl ID | ENSG00000213949 |
| UniProt ID | P56199 |
| OMIM ID | 192968 |
| HGNC ID | 6137 |
| Aliases | CD49a, VLA1, VLA-1 |
Description
ITGA1 encodes the integrin alpha 1 subunit, which heterodimerizes with integrin beta 1 to form the collagen receptor VLA-1 (α1β1). This receptor mediates cell adhesion to collagen types I, IV, and VI, and plays roles in cell migration, proliferation, and extracellular matrix remodeling. ITGA1 is expressed in various tissues including smooth muscle, fibroblasts, and immune cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered ITGA1 expression may influence tumor cell adhesion and metastasis through collagen binding. | NCBI Gene, COSMIC |
| Systemic sclerosis | ITGA1 upregulation in fibroblasts contributes to excessive collagen deposition and fibrosis. | NCBI Gene, OMIM |
| Rheumatoid arthritis | ITGA1 expression on synovial fibroblasts promotes adhesion to cartilage collagen, driving joint destruction. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Smooth muscle | 12.5 | Medium |
| Fibroblasts | 15.2 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Liver | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 10.1 | Moderate expression |
| HCT116 (colorectal carcinoma) | 7.8 | Low expression |
| HEK293 (embryonic kidney) | 5.2 | Low expression |
| MCF7 (breast carcinoma) | 4.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | <0.1% | Unknown functional impact |
| c.567_568del (p.Leu190fs) | Frameshift | <0.01% | Predicted loss of function |
| c.890C>T (p.Thr297Ile) | Missense | <0.05% | Reduced collagen binding in vitro |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants that truncate the protein are predicted to cause loss of integrin function, impairing cell adhesion.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ITGA1.
Dominant Negative (DN)
No dominant-negative mutations described for ITGA1.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • integrin binding (GO:0005178) |
| • plasma membrane (GO:0005886) | • signaling receptor activity (GO:0038023) |
| • receptor complex (GO:0043235) |
Pathways
• Integrin signaling pathway (KEGG: hsa04510)
• ECM-receptor interaction (KEGG: hsa04512)
• Focal adhesion (KEGG: hsa04510)
Protein Summary
Integrin alpha-1 (CD49a) is a 1153-amino-acid transmembrane protein that forms a heterodimer with integrin beta-1. The extracellular domain contains seven FG-GAP repeats that mediate collagen binding, while the cytoplasmic tail interacts with cytoskeletal and signaling proteins. ITGA1 is critical for cell-matrix adhesion, particularly to collagens, and is involved in tissue repair, inflammation, and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ITGA1 Knockout HEK293 Cell Line | EDJ-KQ806 | Human | 3672 | Details Get a Quote |
| ITGA10 Knockout HEK293 Cell Line | EDJ-KQ807 | Human | 8515 | Details Get a Quote |
| ITGA11 Knockout HEK293 Cell Line | EDJ-KQ808 | Human | 22801 | Details Get a Quote |
| ITGA1 Knockout HCT 116 Cell Line | EDJ-KQ18286 | Human | 3672 | Details Get a Quote |
| ITGA1 Knockout A-549 Cell Line | EDJ-KQ19543 | Human | 3672 | Details Get a Quote |
| ITGA1 Knockout HeLa Cell Line | EDJ-KQ19545 | Human | 3672 | Details Get a Quote |
| ITGA10 Knockout HCT 116 Cell Line | EDJ-KQ19546 | Human | 8515 | Details Get a Quote |
| ITGA11 Knockout A-549 Cell Line | EDJ-KQ19547 | Human | 22801 | Details Get a Quote |
| ITGA11 Knockout HeLa Cell Line | EDJ-KQ19548 | Human | 22801 | Details Get a Quote |
| ITGA10 Knockout HeLa Cell Line | EDJ-KQ54926 | Human | 8515 | Details Get a Quote |
| ITGA10 Knockout A-549 Cell Line | EDJ-KQ63412 | Human | 8515 | Details Get a Quote |
| ITGA11 Knockout HCT 116 Cell Line | EDJ-KQ72583 | Human | 22801 | Details Get a Quote |
Displaying Records 1 To 12 Of 12 Records
