IPP Gene (Intracisternal A Particle-Promoted Polypeptide)
Comprehensive gene information for IPP, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | IPP |
|---|---|
| Full Name | Intracisternal A Particle-Promoted Polypeptide |
| Gene Type | protein-coding |
| Chromosomal Location | 1p32.3 |
| NCBI Gene ID | 3652 ncbi.nlm.nih.gov/gene/3652 |
| Ensembl ID | ENSG00000117407 |
| UniProt ID | Q9Y6B2 |
| OMIM ID | 604039 |
| HGNC ID | 6098 |
| Aliases | IAPP, IPP1, IAP |
Description
The IPP gene encodes a protein that is involved in the regulation of cell growth and differentiation. It is located on chromosome 1p32.3 and is associated with various cellular processes. The protein is known to interact with other molecules to modulate signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations confirmed | Not established | No direct evidence from NCBI, OMIM, or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 9.5 | Low expression |
| K562 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G | missense | <0.01% | Unknown |
| c.456C>T | synonymous | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • cytoplasm |
| • nucleus |
Pathways
• No specific pathways documented
Protein Summary
The IPP protein is a 200-amino acid polypeptide that localizes to the cytoplasm and nucleus. It is involved in protein-protein interactions and may play a role in cellular signaling. The exact function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IPPK Knockout HEK293 Cell Line | EDJ-KQ1684 | Human | 64768 | Details Get a Quote |
| IPP Knockout HEK293 Cell Line | EDJ-KQ5002 | Human | 3652 | Details Get a Quote |
| IPPK Knockout HCT 116 Cell Line | EDJ-KQ20128 | Human | 64768 | Details Get a Quote |
| IPPK Knockout A-549 Cell Line | EDJ-KQ21471 | Human | 64768 | Details Get a Quote |
| IPPK Knockout HeLa Cell Line | EDJ-KQ21473 | Human | 64768 | Details Get a Quote |
| IPP Knockout A-549 Cell Line | EDJ-KQ27903 | Human | 3652 | Details Get a Quote |
| IPP Knockout HCT 116 Cell Line | EDJ-KQ27904 | Human | 3652 | Details Get a Quote |
| IPP Knockout HeLa Cell Line | EDJ-KQ27905 | Human | 3652 | Details Get a Quote |
