INHBC Gene (Inhibin Subunit Beta C)
A member of the TGF-beta superfamily involved in reproductive function and cell growth regulation
Gene Information Card
| Symbol | INHBC |
|---|---|
| Full Name | Inhibin Subunit Beta C |
| Gene Type | protein-coding |
| Chromosomal Location | 12q13.3 |
| NCBI Gene ID | 3623 ncbi.nlm.nih.gov/gene/3623 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | P55103 |
| OMIM ID | 601233 |
| HGNC ID | 6067 |
| Aliases | IHBC, activin beta-C chain |
Description
The INHBC gene encodes the beta C subunit of inhibin, a member of the transforming growth factor-beta (TGF-beta) superfamily. Inhibins are heterodimeric hormones that regulate pituitary follicle-stimulating hormone (FSH) secretion and have roles in gonadal function, embryonic development, and cell proliferation. The beta C subunit can form activin complexes (e.g., activin C) that modulate signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered INHBC expression may disrupt activin/inhibin balance, affecting cell growth and differentiation. | PMID: 10652318 |
| Ovarian cancer | Dysregulation of inhibin subunits, including INHBC, is associated with tumor progression and hormone secretion. | PMID: 11585764 |
| Endometrial cancer | Aberrant expression of INHBC contributes to abnormal TGF-beta signaling in endometrial tissue. | PMID: 12117752 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Ovary | 0.6 | Low |
| Prostate | 0.5 | Low |
| Endometrium | 0.4 | Low |
| Liver | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 0.7 | Moderate expression |
| OVCAR-3 (ovarian cancer) | 0.5 | Low expression |
| HepG2 (liver cancer) | 0.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.100G>A (p.Gly34Arg) | missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (KEGG: hsa04350)
• Activin receptor signaling (Reactome: R-HSA-1502540)
Protein Summary
Inhibin beta C chain (UniProt P55103) is a 352-amino acid protein that dimerizes with other inhibin/activin subunits to form bioactive ligands. It contains a conserved TGF-beta domain and is secreted as part of heterodimeric complexes. The protein is involved in regulating FSH secretion and modulating cell proliferation, differentiation, and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| INHBC Knockout HEK293 Cell Line | EDJ-KQ386 | Human | 3626 | Details Get a Quote |
| INHBC Knockout HeLa Cell Line | EDJ-KQ53663 | Human | 3626 | Details Get a Quote |
| INHBC Knockout A-549 Cell Line | EDJ-KQ62137 | Human | 3626 | Details Get a Quote |
| INHBC Knockout HCT 116 Cell Line | EDJ-KQ70627 | Human | 3626 | Details Get a Quote |
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