ING4: Inhibitor of Growth Family Member 4
A tumor suppressor gene involved in cell cycle regulation, apoptosis, and DNA repair
Gene Information Card
| Symbol | ING4 |
|---|---|
| Full Name | Inhibitor of growth family member 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.31 |
| NCBI Gene ID | 51147 ncbi.nlm.nih.gov/gene/51147 |
| Ensembl ID | ENSG00000111666 |
| UniProt ID | Q9UNL4 |
| OMIM ID | 607724 |
| HGNC ID | 19423 |
| Aliases | p29ING4, My036, ING4a, ING4b |
Description
ING4 (inhibitor of growth family member 4) is a tumor suppressor gene that encodes a protein involved in cell cycle arrest, apoptosis, DNA repair, and chromatin remodeling. It interacts with p53 and the HBO1 histone acetyltransferase complex to regulate gene expression. ING4 is frequently downregulated or mutated in various cancers, contributing to tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Loss of ING4 expression promotes cell proliferation and invasion via NF-κB and HIF-1α pathways | PMID: 19029980 |
| Glioma | ING4 suppresses angiogenesis and tumor growth by inhibiting NF-κB and HIF-1α | PMID: 15156121 |
| Head and neck squamous cell carcinoma | Reduced ING4 expression correlates with poor prognosis and increased metastasis | PMID: 19137017 |
| Melanoma | ING4 downregulation enhances tumor growth and metastasis through PI3K/AKT pathway | PMID: 20053722 |
| Gastric cancer | ING4 inhibits cell proliferation and induces apoptosis via p53-dependent pathway | PMID: 21532990 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Liver | 6.7 | Low |
| Lung | 14.8 | Medium |
| Ovary | 9.4 | Low |
| Prostate | 11.0 | Medium |
| Skin | 7.2 | Low |
| Testis | 18.6 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 16.3 | Cervical cancer cell line |
| MCF7 | 12.1 | Breast cancer cell line |
| A549 | 14.5 | Lung cancer cell line |
| HCT116 | 13.8 | Colorectal cancer cell line |
| U87MG | 11.2 | Glioblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Loss of start codon, likely loss of function |
| c.205C>T (p.Arg69Trp) | Missense | Rare | Reduced interaction with p53 |
| c.364G>A (p.Glu122Lys) | Missense | Rare | Altered chromatin binding |
| c.511C>T (p.Arg171*) | Nonsense | Rare | Premature truncation, loss of function |
Mutation functional classification
Loss of Function (LOF)
Most ING4 mutations (e.g., nonsense, frameshift, missense in conserved domains) lead to loss of tumor suppressor activity, reduced p53 binding, and impaired chromatin remodeling.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in ING4.
Dominant Negative (DN)
Some missense mutations (e.g., p.Arg69Trp) may act in a dominant-negative manner by interfering with wild-type ING4 function in protein complexes.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • nucleoplasm (GO:0005654) | • chromatin organization (GO:0006325) |
| • transcription (GO:0006351) | • apoptotic process (GO:0006915) |
| • cell cycle (GO:0007049) | • cell proliferation (GO:0008283) |
| • covalent chromatin modification (GO:0016569) | • negative regulation of apoptotic process (GO:0043066) |
Pathways
• p53 signaling pathway (KEGG: hsa04115)
• Cell cycle (KEGG: hsa04110)
• Apoptosis (KEGG: hsa04210)
• HIF-1 signaling pathway (KEGG: hsa04066)
• NF-kappa B signaling pathway (KEGG: hsa04064)
Protein Summary
The ING4 protein (UniProt Q9UNL4) is a 249-amino acid nuclear protein containing a PHD finger domain that binds to histone H3 trimethylated at lysine 4 (H3K4me3). It functions as a tumor suppressor by recruiting the HBO1 histone acetyltransferase complex to chromatin, promoting histone acetylation and gene expression. ING4 also interacts with p53 to enhance its transcriptional activity, leading to cell cycle arrest and apoptosis. Additionally, it negatively regulates NF-κB and HIF-1α signaling, suppressing angiogenesis and metastasis. ING4 is widely expressed in normal tissues but frequently downregulated in cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ING4 Knockout HEK293 Cell Line | EDJ-KQ10950 | Human | 51147 | Details Get a Quote |
| ING4 Knockout A-549 Cell Line | EDJ-KQ37443 | Human | 51147 | Details Get a Quote |
| ING4 Knockout HCT 116 Cell Line | EDJ-KQ38750 | Human | 51147 | Details Get a Quote |
| ING4 Knockout HeLa Cell Line | EDJ-KQ38751 | Human | 51147 | Details Get a Quote |
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