ING3 Gene - Inhibitor of Growth Family Member 3
A tumor suppressor gene involved in chromatin remodeling, cell cycle regulation, and apoptosis.
Gene Information Card
| Symbol | ING3 |
|---|---|
| Full Name | inhibitor of growth family member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q31.31 |
| NCBI Gene ID | 54556 ncbi.nlm.nih.gov/gene/54556 |
| Ensembl ID | ENSG00000106031 |
| UniProt ID | Q9NXR8 |
| OMIM ID | 607493 |
| HGNC ID | 6089 |
| Aliases | Eaf4, ING3, p47ING3, MEAF4 |
Description
The ING3 gene encodes a member of the inhibitor of growth (ING) family of tumor suppressors. The protein contains a plant homeodomain (PHD) finger, which binds to histone H3 trimethylated at lysine 4 (H3K4me3), and is a component of the NuA4 histone acetyltransferase complex. ING3 functions in chromatin remodeling, transcriptional regulation, cell cycle arrest, and apoptosis. It is frequently downregulated or mutated in various cancers, suggesting a role in tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Head and neck squamous cell carcinoma | Loss of ING3 expression leads to reduced apoptosis and increased proliferation | PMID: 18369447; COSMIC |
| Melanoma | Decreased ING3 expression correlates with tumor progression and poor prognosis | PMID: 17909063; ClinVar |
| Breast cancer | ING3 downregulation associated with aggressive tumor phenotypes | PMID: 21351256; NCBI Gene |
| Colorectal cancer | Reduced ING3 expression linked to metastasis and worse survival | PMID: 23175147; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.3 | Medium |
| Lymph node | 7.1 | Medium |
| Bone marrow | 6.8 | Low |
| Brain | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.8 | Embryonic kidney; moderate expression |
| HeLa | 7.5 | Cervical carcinoma; moderate expression |
| MCF7 | 6.1 | Breast cancer; low expression |
| A549 | 5.4 | Lung carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Pro166Leu) | Missense | 0.02% (gnomAD) | Unknown; may affect PHD finger function |
| c.103G>A (p.Gly35Arg) | Missense | 0.01% (gnomAD) | Unknown; located in N-terminal region |
| c.1A>G (p.Met1?) | Start loss | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift or nonsense mutations leading to truncated protein or loss of PHD finger are predicted to impair chromatin binding and tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for ING3.
Dominant Negative (DN)
Missense mutations in the PHD finger may disrupt histone binding and exert dominant-negative effects, but evidence is limited.
View complete mutation data：
Gene Ontology (GO)
Pathways
• NuA4 histone acetyltransferase complex
• p53 signaling pathway
• Apoptosis
• Cell cycle - G1/S transition
Protein Summary
ING3 is a 47 kDa nuclear protein containing a PHD finger that specifically recognizes trimethylated histone H3 at lysine 4 (H3K4me3). It is a stable component of the NuA4/Tip60 histone acetyltransferase complex, which acetylates histones and non-histone proteins such as p53. Through this complex, ING3 regulates transcription of genes involved in cell cycle arrest, DNA repair, and apoptosis. Loss of ING3 expression or function contributes to tumorigenesis in multiple cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ING3 Knockout HEK293 Cell Line | EDJ-KQ11464 | Human | 54556 | Details Get a Quote |
| ING3 Knockout HCT 116 Cell Line | EDJ-KQ39761 | Human | 54556 | Details Get a Quote |
| ING3 Knockout HeLa Cell Line | EDJ-KQ39762 | Human | 54556 | Details Get a Quote |
| ING3 Knockout A-549 Cell Line | EDJ-KQ64933 | Human | 54556 | Details Get a Quote |
