ING1: Inhibitor of Growth Family Member 1
A tumor suppressor gene involved in cell cycle regulation, apoptosis, and chromatin remodeling.
Gene Information Card
| Symbol | ING1 |
|---|---|
| Full Name | inhibitor of growth family member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q34 |
| NCBI Gene ID | 3621 ncbi.nlm.nih.gov/gene/3621 |
| Ensembl ID | ENSG00000120868 |
| UniProt ID | Q9UK53 |
| OMIM ID | 601566 |
| HGNC ID | 6062 |
| Aliases | p33ING1, p33ING1b, ING1a, ING1b, ING1c |
Description
The ING1 (inhibitor of growth family member 1) gene encodes a tumor suppressor protein that regulates cell cycle progression, apoptosis, and chromatin remodeling. It is a member of the ING family of proteins, which contain a plant homeodomain (PHD) finger that binds to histone H3 trimethylated at lysine 4 (H3K4me3). ING1 interacts with the p53 signaling pathway and is frequently downregulated or mutated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Loss of ING1 expression leads to reduced p53-mediated apoptosis and increased cell proliferation. | PMID: 10655551, COSMIC |
| Head and neck squamous cell carcinoma | Decreased ING1 expression correlates with tumor progression and poor prognosis. | PMID: 11994725 |
| Melanoma | ING1 mutations and loss of heterozygosity contribute to tumorigenesis. | PMID: 12592314 |
| Gastric cancer | Reduced ING1 expression is associated with advanced tumor stage and lymph node metastasis. | PMID: 15042678 |
| Lung cancer | ING1 downregulation promotes cell cycle progression and resistance to apoptosis. | PMID: 15586223 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 8.2 | Medium |
| Lung | 6.5 | Medium |
| Colon | 5.1 | Low |
| Skin | 4.8 | Low |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 9.1 | High expression |
| A549 (lung cancer) | 7.3 | Medium expression |
| HeLa (cervical cancer) | 6.8 | Medium expression |
| HCT116 (colon cancer) | 5.4 | Low expression |
| SK-MEL-28 (melanoma) | 4.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.364C>T (p.Arg122*) | Nonsense | Rare | Truncation leading to loss of function |
| c.497G>A (p.Arg166Gln) | Missense | Rare | Reduced binding to p53 and impaired growth suppression |
| c.1A>G (p.Met1?) | Start loss | Rare | Loss of translation initiation |
| c.103_104del (p.Leu35fs) | Frameshift | Rare | Premature termination and loss of function |
Mutation functional classification
Loss of Function (LOF)
Most ING1 mutations result in loss of tumor suppressor activity, including impaired p53 interaction and reduced apoptosis.
Gain of Function (GOF)
No gain-of-function mutations have been reported for ING1.
Dominant Negative (DN)
Some missense mutations (e.g., p.Arg166Gln) may act in a dominant-negative manner by competing with wild-type ING1 for binding partners.
View complete mutation data：
Gene Ontology (GO)
Pathways
• p53 signaling pathway (KEGG: hsa04115)
• Apoptosis (KEGG: hsa04210)
• Cell cycle (KEGG: hsa04110)
Protein Summary
The ING1 protein (p33ING1) is a 33 kDa nuclear protein containing a PHD finger domain that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3). It functions as a chromatin reader and recruits histone acetyltransferase (HAT) complexes to promote gene expression. ING1 enhances p53 acetylation and stability, thereby inducing cell cycle arrest and apoptosis in response to DNA damage. It also interacts with PCNA and is involved in DNA repair. Loss of ING1 expression or function contributes to tumorigenesis in multiple cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ING1 Knockout HEK293 Cell Line | EDJ-KQ4996 | Human | 3621 | Details Get a Quote |
| ING1 Knockout HCT 116 Cell Line | EDJ-KQ26678 | Human | 3621 | Details Get a Quote |
| ING1 Knockout A-549 Cell Line | EDJ-KQ27893 | Human | 3621 | Details Get a Quote |
| ING1 Knockout HeLa Cell Line | EDJ-KQ27894 | Human | 3621 | Details Get a Quote |
