IL32 Gene - Interleukin 32
Cytokine with roles in inflammation, infection, and cancer
Gene Information Card
| Symbol | IL32 |
|---|---|
| Full Name | interleukin 32 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 9235 ncbi.nlm.nih.gov/gene/9235 |
| Ensembl ID | ENSG00000008517 |
| UniProt ID | P24001 |
| OMIM ID | 606001 |
| HGNC ID | 16830 |
| Aliases | NK4, TAIF, IL-32, IL32alpha, IL32beta, IL32gamma |
Description
IL32 (interleukin 32) is a pro-inflammatory cytokine that induces the production of TNFα, IL-1β, and IL-6. It is expressed in various tissues and cell types, particularly in immune cells, and plays a role in inflammatory diseases, infections, and cancer. IL32 has multiple splice variants with distinct biological activities.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | IL32 is overexpressed in synovial tissue and promotes TNFα and IL-1β production, contributing to joint inflammation | PMID: 15630446 |
| Chronic Obstructive Pulmonary Disease (COPD) | IL32 levels are elevated in lung epithelium and macrophages, enhancing inflammatory cytokine release | PMID: 18403664 |
| Gastric Cancer | IL32 expression is associated with tumor progression and metastasis via NF-κB activation | PMID: 21573172 |
| HIV-1 Infection | IL32 is induced by HIV-1 and modulates viral replication through cytokine signaling | PMID: 16912299 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Lymph node | 9.2 | Medium |
| Bone marrow | 7.6 | Low |
| Small intestine | 6.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.3 | High expression after LPS stimulation |
| A549 (lung epithelial) | 8.1 | Moderate constitutive expression |
| Jurkat (T-cell) | 5.2 | Low basal expression |
| HeLa (cervical) | 4.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | p.Met1Val; potential start codon loss |
| c.124G>A | missense | <0.01% | p.Gly42Ser; unknown functional effect |
| c.346C>T | synonymous | 0.02% | p.Leu116Leu; no amino acid change |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in IL32.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in IL32.
Dominant Negative (DN)
No dominant-negative mutations reported in IL32.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04668 (TNF signaling pathway)
• hsa04620 (Toll-like receptor signaling pathway)
• hsa05164 (Influenza A)
Protein Summary
Interleukin 32 (IL-32) is a 131-amino acid cytokine with no sequence homology to other known interleukins. It is produced as multiple splice variants (alpha, beta, gamma, delta, epsilon, zeta, eta, theta, iota, kappa) that differ in biological activity. IL-32 induces pro-inflammatory cytokines via NF-κB and p38 MAPK pathways. It is implicated in autoimmune diseases, chronic inflammation, and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL32 Knockout HEK293 Cell Line | EDJ-KQ6513 | Human | 9235 | Details Get a Quote |
| IL32 Knockout A-549 Cell Line | EDJ-KQ29312 | Human | 9235 | Details Get a Quote |
| IL32 Knockout HCT 116 Cell Line | EDJ-KQ30657 | Human | 9235 | Details Get a Quote |
| IL32 Knockout HeLa Cell Line | EDJ-KQ30658 | Human | 9235 | Details Get a Quote |
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