IL31 Gene - Interleukin 31
Comprehensive genomic and functional analysis of IL31, a cytokine involved in pruritus and inflammatory skin diseases.
Gene Information Card
| Symbol | IL31 |
|---|---|
| Full Name | Interleukin 31 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 386653 ncbi.nlm.nih.gov/gene/386653 |
| Ensembl ID | ENSG00000164535 |
| UniProt ID | Q6EBC2 |
| OMIM ID | 609510 |
| HGNC ID | 19372 |
| Aliases | IL-31 |
Description
IL31 (interleukin 31) is a cytokine gene located on chromosome 12q24.31. It encodes a 164-amino acid protein that belongs to the IL-6 cytokine family. IL31 signals through a heterodimeric receptor composed of IL31RA and OSMR. It is primarily produced by activated Th2 cells and plays a key role in pruritus (itching), inflammation, and immune regulation. Dysregulation of IL31 is implicated in atopic dermatitis, prurigo nodularis, and other inflammatory skin conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atopic Dermatitis | IL31 overexpression promotes Th2 inflammation and pruritus via IL31RA signaling in sensory neurons. | NCBI Gene, OMIM |
| Prurigo Nodularis | Elevated IL31 levels correlate with chronic itch and nodular skin lesions. | NCBI Gene, OMIM |
| Allergic Contact Dermatitis | IL31 contributes to itch and inflammation in allergen-exposed skin. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 0.4 | Low |
| Lung | 0.1 | Not detected |
| Testis | 0.2 | Not detected |
| Thymus | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | Not detected |
| K-562 | 0.0 | Not detected |
| MCF7 | 0.0 | Not detected |
| Activated CD4+ T cells | 2.5 | Low (induced) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs79751784 | SNV | <0.01% | Missense, uncertain significance |
| rs201516674 | SNV | <0.01% | Missense, uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported; overexpression is associated with disease.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-31 signaling pathway (Reactome: R-HSA-6783589)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• JAK-STAT signaling pathway (KEGG: hsa04630)
Protein Summary
Interleukin 31 (IL-31) is a 164-amino acid cytokine with a four-helix bundle structure. It is secreted by activated Th2 cells and binds to the IL31RA/OSMR receptor complex, activating JAK-STAT, PI3K/AKT, and MAPK pathways. IL-31 induces pruritus by directly stimulating sensory neurons and promotes inflammation by upregulating chemokines and cytokines in keratinocytes and immune cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL31RA Knockout HEK293 Cell Line | EDJ-KQ3651 | Human | 133396 | Details Get a Quote |
| IL31 Knockout HEK293 Cell Line | EDJ-KQ13827 | Human | 386653 | Details Get a Quote |
| IL31RA Knockout A-549 Cell Line | EDJ-KQ25620 | Human | 133396 | Details Get a Quote |
| IL31RA Knockout HeLa Cell Line | EDJ-KQ58326 | Human | 133396 | Details Get a Quote |
| IL31 Knockout HeLa Cell Line | EDJ-KQ59952 | Human | 386653 | Details Get a Quote |
| IL31 Knockout A-549 Cell Line | EDJ-KQ68413 | Human | 386653 | Details Get a Quote |
| IL31RA Knockout HCT 116 Cell Line | EDJ-KQ75217 | Human | 133396 | Details Get a Quote |
| IL31 Knockout HCT 116 Cell Line | EDJ-KQ76792 | Human | 386653 | Details Get a Quote |
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