IL3 Gene - Interleukin 3
Cytokine involved in hematopoiesis and immune regulation
Gene Information Card
| Symbol | IL3 |
|---|---|
| Full Name | Interleukin 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 3562 ncbi.nlm.nih.gov/gene/3562 |
| Ensembl ID | ENSG00000164399 |
| UniProt ID | P08700 |
| OMIM ID | 147740 |
| HGNC ID | 6011 |
| Aliases | MCGF, MULTI-CSF, IL-3 |
Description
IL3 (Interleukin 3) is a protein-coding gene located on chromosome 5q31.1. It encodes a cytokine that regulates hematopoiesis by stimulating the proliferation and differentiation of multipotent hematopoietic stem cells and various progenitor cells, including granulocytes, macrophages, mast cells, and erythroid cells. IL3 is primarily produced by activated T cells, mast cells, and eosinophils. The gene is part of the interleukin family and is involved in immune responses and inflammatory processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | IL3 contributes to airway inflammation by promoting eosinophil and mast cell activation. | ClinVar, NCBI |
| Myeloid leukemia | Dysregulated IL3 signaling can promote abnormal proliferation of myeloid progenitors. | COSMIC, NCBI |
| Allergic rhinitis | IL3 levels are elevated in allergic responses, supporting eosinophil survival. | ClinVar, NCBI |
| Mastocytosis | IL3 stimulates mast cell growth and may contribute to mast cell accumulation. | OMIM, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 0.2 | Low |
| Spleen | 0.1 | Low |
| Lung | 0.0 | Not detected |
| Blood | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 0.0 | Not detected |
| HEK 293 | 0.0 | Not detected |
| Jurkat | 0.0 | Not detected |
| HUVEC | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Likely benign; no functional impact reported |
| c.100C>T | SNV | <0.01% | Missense; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in IL3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in IL3.
Dominant Negative (DN)
No dominant-negative mutations reported in IL3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hematopoietic cell lineage (KEGG: hsa04640)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• JAK-STAT signaling pathway (KEGG: hsa04630)
• IL-3 signaling pathway (Reactome: R-HSA-512988)
Protein Summary
IL3 encodes a 152-amino acid cytokine (UniProt P08700) that is secreted as a glycoprotein. It binds to the IL3 receptor (IL3RA/CD123) and signals through the JAK-STAT pathway, promoting cell survival, proliferation, and differentiation in hematopoietic cells. The protein is a key regulator of hematopoiesis and immune responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NEIL3 Knockout HEK293 Cell Line | EDJ-KQ1011 | Human | 55247 | Details Get a Quote |
| IL33 Knockout HEK293 Cell Line | EDJ-KQ1106 | Human | 90865 | Details Get a Quote |
| IL37 Knockout HEK293 Cell Line | EDJ-KQ1410 | Human | 27178 | Details Get a Quote |
| IL36RN Knockout HEK293 Cell Line | EDJ-KQ2688 | Human | 26525 | Details Get a Quote |
| NFIL3 Knockout HEK293 Cell Line | EDJ-KQ2720 | Human | 4783 | Details Get a Quote |
| IL31RA Knockout HEK293 Cell Line | EDJ-KQ3651 | Human | 133396 | Details Get a Quote |
| IL32 Knockout HEK293 Cell Line | EDJ-KQ6513 | Human | 9235 | Details Get a Quote |
| EDIL3 Knockout HEK293 Cell Line | EDJ-KQ6891 | Human | 10085 | Details Get a Quote |
| IL36A Knockout HEK293 Cell Line | EDJ-KQ7970 | Human | 27179 | Details Get a Quote |
| IL36B Knockout HEK293 Cell Line | EDJ-KQ8709 | Human | 27177 | Details Get a Quote |
| IL34 Knockout HEK293 Cell Line | EDJ-KQ10480 | Human | 146433 | Details Get a Quote |
| CARMIL3 Knockout HEK293 Cell Line | EDJ-KQ10629 | Human | 90668 | Details Get a Quote |
| PPIL3 Knockout HEK293 Cell Line | EDJ-KQ11371 | Human | 53938 | Details Get a Quote |
| IL31 Knockout HEK293 Cell Line | EDJ-KQ13827 | Human | 386653 | Details Get a Quote |
| IL36G Knockout HEK293 Cell Line | EDJ-KQ13828 | Human | 56300 | Details Get a Quote |
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