IL24 Gene - Interleukin 24
Comprehensive gene card for IL24, a cytokine with tumor suppressor and immunomodulatory functions.
Gene Information Card
| Symbol | IL24 |
|---|---|
| Full Name | Interleukin 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 11009 ncbi.nlm.nih.gov/gene/11009 |
| Ensembl ID | ENSG00000162892 |
| UniProt ID | Q13007 |
| OMIM ID | 604535 |
| HGNC ID | 5990 |
| Aliases | MDA-7, FISP, ST16, IL-24, C49A |
Description
IL24 (Interleukin 24) is a member of the IL-10 family of cytokines. It is primarily expressed in immune cells and skin, and functions as a tumor suppressor by inducing apoptosis selectively in cancer cells. IL24 also plays roles in wound healing, inflammation, and immune regulation. The gene is located on chromosome 1q32.1 and encodes a secreted protein that signals through IL-20 receptor complexes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Melanoma | IL24 induces apoptosis via endoplasmic reticulum stress and mitochondrial pathways; loss of IL24 expression contributes to tumor progression. | PMID: 11526407; NCBI Gene |
| Breast Cancer | IL24 overexpression suppresses tumor growth and metastasis through anti-angiogenic and pro-apoptotic mechanisms. | PMID: 15569927; COSMIC |
| Psoriasis | IL24 is upregulated in psoriatic skin lesions and may contribute to inflammation and keratinocyte hyperproliferation. | PMID: 12640457; OMIM |
| Rheumatoid Arthritis | IL24 levels are elevated in synovial fluid and serum, promoting inflammatory cytokine production. | PMID: 19116917; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Bone Marrow | 4.7 | Low |
| Lymph Node | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung Cancer) | 2.1 | Low expression |
| MCF7 (Breast Cancer) | 1.5 | Low expression |
| HaCaT (Keratinocyte) | 15.3 | Moderate expression |
| THP-1 (Monocyte) | 5.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Likely benign; no functional data |
| c.214C>T | Nonsense | <0.01% | Predicted loss-of-function; truncation |
| c.389G>A | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in IL24 are predicted to cause loss of tumor suppressor activity, potentially contributing to cancer progression.
Gain of Function (GOF)
No gain-of-function mutations have been reported in IL24.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for IL24.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-10 family signaling pathway (Reactome: R-HSA-6783783)
• Apoptosis (KEGG: hsa04210)
• JAK-STAT signaling pathway (KEGG: hsa04630)
Protein Summary
IL24 is a 206-amino acid secreted cytokine with a signal peptide (residues 1-48) and a mature region (49-206). It contains an IL-10 family signature domain. The protein binds to IL-20R1/IL-20R2 or IL-22R1/IL-20R2 receptor complexes, activating STAT3 signaling. IL24 selectively induces apoptosis in cancer cells via endoplasmic reticulum stress and reactive oxygen species production, while sparing normal cells. It also modulates immune responses and angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL24 Knockout HEK293 Cell Line | EDJ-KQ133 | Human | 11009 | Details Get a Quote |
| IL24 Knockout HeLa Cell Line | EDJ-KQ55543 | Human | 11009 | Details Get a Quote |
| IL24 Knockout A-549 Cell Line | EDJ-KQ64037 | Human | 11009 | Details Get a Quote |
| IL24 Knockout HCT 116 Cell Line | EDJ-KQ72487 | Human | 11009 | Details Get a Quote |
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