IL22RA2
Interleukin 22 Receptor Subunit Alpha 2
Gene Information Card
| Symbol | IL22RA2 |
|---|---|
| Full Name | Interleukin 22 Receptor Subunit Alpha 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q23.3 |
| NCBI Gene ID | 116379 ncbi.nlm.nih.gov/gene/116379 |
| Ensembl ID | ENSG00000124813 |
| UniProt ID | Q969J5 |
| OMIM ID | 606648 |
| HGNC ID | 16300 |
| Aliases | IL-22BP, IL22BP, CRF2-10, CRF2S1 |
Description
IL22RA2 (Interleukin 22 Receptor Subunit Alpha 2) encodes a soluble receptor that binds interleukin-22 (IL-22) with high affinity, acting as a natural antagonist. It is expressed in various tissues and immune cells, regulating IL-22 signaling in inflammation, tissue repair, and barrier immunity. The gene is located on chromosome 6q23.3 and is associated with several inflammatory and autoimmune conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | IL22RA2 polymorphisms may alter IL-22 neutralization, affecting mucosal immunity | PMID: 21102463 |
| Psoriasis | Elevated IL22RA2 expression in skin lesions may modulate IL-22-driven keratinocyte proliferation | PMID: 24120358 |
| Rheumatoid Arthritis | IL22RA2 levels in synovial fluid correlate with disease activity | PMID: 21862680 |
| Colorectal Cancer | IL22RA2 expression in tumor microenvironment may influence IL-22-mediated tumor growth | PMID: 25242043 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Medium |
| Small Intestine | 4.8 | Medium |
| Colon | 4.5 | Medium |
| Skin | 3.9 | Low |
| Spleen | 3.1 | Low |
| Lymph Node | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 6.1 | Differentiated macrophages show higher expression |
| Jurkat (T-cell) | 2.3 | Low expression |
| HeLa (cervical) | 1.5 | Very low expression |
| A549 (lung) | 4.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs28385692 | SNP | 0.5% (global) | Intronic variant; potential association with IBD |
| rs17066096 | SNP | 1.2% (European) | Missense; may affect IL-22 binding affinity |
| c.256G>A | Missense | Rare | p.Gly86Arg; unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Rare nonsense or frameshift mutations predicted to truncate the protein, reducing IL-22 binding capacity.
Gain of Function (GOF)
Not well characterized; potential missense variants increasing IL-22 affinity are speculative.
Dominant Negative (DN)
No dominant-negative mutations reported for IL22RA2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-22 Signaling Pathway (Reactome: R-HSA-8984722)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
IL22RA2 encodes a 34 kDa soluble protein (IL-22BP) that belongs to the class II cytokine receptor family. It binds IL-22 with high affinity (Kd ~1 pM) and prevents IL-22 from interacting with the membrane-bound IL-22R1/IL-10R2 complex, thereby inhibiting downstream STAT3 signaling. IL-22BP is constitutively expressed in dendritic cells, macrophages, and epithelial cells, and its levels are modulated during inflammation. The protein plays a critical role in balancing IL-22-mediated tissue protection and pro-inflammatory responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL22RA2 Knockout HEK293 Cell Line | EDJ-KQ490 | Human | 116379 | Details Get a Quote |
| IL22RA2 Knockout HeLa Cell Line | EDJ-KQ57983 | Human | 116379 | Details Get a Quote |
| IL22RA2 Knockout A-549 Cell Line | EDJ-KQ66471 | Human | 116379 | Details Get a Quote |
| IL22RA2 Knockout HCT 116 Cell Line | EDJ-KQ74893 | Human | 116379 | Details Get a Quote |
