IL22RA1 Gene
Interleukin 22 Receptor Subunit Alpha 1
Gene Information Card
| Symbol | IL22RA1 |
|---|---|
| Full Name | Interleukin 22 Receptor Subunit Alpha 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.11 |
| NCBI Gene ID | 58985 ncbi.nlm.nih.gov/gene/58985 |
| Ensembl ID | ENSG00000142677 |
| UniProt ID | Q8N6P7 |
| OMIM ID | 605457 |
| HGNC ID | 13700 |
| Aliases | IL22R, IL22RA, CRF2-9, IL-22R1 |
Description
IL22RA1 encodes a subunit of the interleukin 22 receptor complex. This protein forms a heterodimer with IL10RB to mediate IL-22 signaling, which is involved in tissue protection, regeneration, and antimicrobial defense at epithelial barriers. IL22RA1 is primarily expressed on epithelial cells of the skin, digestive tract, and respiratory tract.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | Dysregulated IL-22 signaling via IL22RA1 may impair epithelial barrier function | ClinVar |
| Psoriasis | IL22RA1-mediated IL-22 signaling contributes to epidermal hyperplasia and inflammation | NCBI Gene |
| Colorectal Cancer | IL22RA1 overexpression may promote tumor growth through STAT3 activation | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Colon | 9.8 | Medium |
| Small Intestine | 8.2 | Medium |
| Lung | 6.1 | Low |
| Kidney | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 15.2 | High expression |
| Caco-2 (colorectal) | 10.1 | Medium expression |
| A549 (lung) | 5.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.538G>A (p.Gly180Arg) | Missense | <0.01% | Unknown significance |
| c.1024C>T (p.Arg342Trp) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No dominant negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • interleukin-22 receptor activity | • cytokine receptor activity |
| • signal transduction | • JAK-STAT cascade |
| • positive regulation of cell proliferation |
Pathways
• IL-22 signaling pathway
• JAK-STAT signaling pathway
• Cytokine-cytokine receptor interaction
Protein Summary
IL22RA1 is a 574-amino acid transmembrane glycoprotein that serves as the specific ligand-binding subunit of the IL-22 receptor. It associates with IL10RB to form a functional receptor complex. Upon IL-22 binding, it activates JAK1 and TYK2, leading to STAT3 phosphorylation and downstream transcriptional responses involved in epithelial homeostasis and antimicrobial defense.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL22RA1 Knockout HEK293 Cell Line | EDJ-KQ13091 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout A-549 Cell Line | EDJ-KQ43650 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout HCT 116 Cell Line | EDJ-KQ43651 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout HeLa Cell Line | EDJ-KQ43652 | Human | 58985 | Details Get a Quote |
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