IL22 Gene: Interleukin 22
Comprehensive gene card for IL22, including genomic context, expression, mutations, and clinical significance.
Gene Information Card
| Symbol | IL22 |
|---|---|
| Full Name | Interleukin 22 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q15 |
| NCBI Gene ID | 50616 ncbi.nlm.nih.gov/gene/50616 |
| Ensembl ID | ENSG00000127324 |
| UniProt ID | Q9GZX6 |
| OMIM ID | 605330 |
| HGNC ID | 14939 |
| Aliases | IL-22, IL-TIF, ILTIF, zcyto18 |
Description
IL22 (Interleukin 22) is a member of the IL-10 family of cytokines. It is produced by Th17 cells, Th22 cells, NK cells, and innate lymphoid cells. IL22 signals through a heterodimeric receptor composed of IL22RA1 and IL10RB, activating STAT3 and MAPK pathways. It plays key roles in mucosal immunity, tissue repair, and antimicrobial defense, particularly in epithelial cells of the skin, intestine, and respiratory tract. Dysregulation of IL22 is implicated in inflammatory diseases such as psoriasis, inflammatory bowel disease (IBD), and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Psoriasis | IL22 overexpression drives keratinocyte hyperproliferation and inflammation via STAT3 activation. | PMID: 19234213, 24958822 |
| Inflammatory Bowel Disease (IBD) | IL22 promotes epithelial barrier integrity and antimicrobial peptide production; dysregulation contributes to chronic inflammation. | PMID: 18641395, 23543747 |
| Rheumatoid Arthritis | IL22 levels elevated in synovial fluid; promotes osteoclastogenesis and joint inflammation. | PMID: 21593343 |
| Gastric Cancer | IL22 signaling via STAT3 promotes tumor cell proliferation and survival. | PMID: 24714568 |
| Colorectal Cancer | IL22 can promote tumorigenesis through STAT3-mediated proliferation and anti-apoptotic signals. | PMID: 22895138 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small Intestine | 0.8 | Low |
| Colon | 0.6 | Low |
| Skin | 0.4 | Low |
| Lung | 0.3 | Low |
| Spleen | 0.2 | Low |
| Thymus | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Th17 cells | Not quantified | Major source of IL22 |
| Th22 cells | Not quantified | Major source of IL22 |
| NK cells | Not quantified | Produce IL22 upon activation |
| ILC3 (innate lymphoid cells) | Not quantified | Produce IL22 in mucosal tissues |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1179251 | SNP | 0.15 (global) | Intronic; associated with psoriasis risk in GWAS |
| rs2227485 | SNP | 0.10 (global) | Missense (Val>Ile); potential functional impact |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in IL22.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in IL22.
Dominant Negative (DN)
No dominant-negative mutations reported in IL22.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-22 signaling pathway (Reactome: R-HSA-8984722)
• JAK-STAT signaling pathway (KEGG: hsa04630)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
IL22 is a 179-amino-acid cytokine (UniProt Q9GZX6) with a signal peptide (residues 1-33) and a mature chain (34-179). It adopts a typical alpha-helical cytokine fold. IL22 binds to the IL22RA1/IL10RB receptor complex, activating STAT3, MAPK, and PI3K/AKT pathways. It is primarily produced by immune cells and acts on non-hematopoietic epithelial cells to promote antimicrobial defense, tissue repair, and barrier integrity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL22 Knockout HEK293 Cell Line | EDJ-KQ489 | Human | 50616 | Details Get a Quote |
| IL22RA2 Knockout HEK293 Cell Line | EDJ-KQ490 | Human | 116379 | Details Get a Quote |
| IL22RA1 Knockout HEK293 Cell Line | EDJ-KQ13091 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout A-549 Cell Line | EDJ-KQ43650 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout HCT 116 Cell Line | EDJ-KQ43651 | Human | 58985 | Details Get a Quote |
| IL22RA1 Knockout HeLa Cell Line | EDJ-KQ43652 | Human | 58985 | Details Get a Quote |
| IL22 Knockout HeLa Cell Line | EDJ-KQ56174 | Human | 50616 | Details Get a Quote |
| IL22RA2 Knockout HeLa Cell Line | EDJ-KQ57983 | Human | 116379 | Details Get a Quote |
| IL22 Knockout A-549 Cell Line | EDJ-KQ64664 | Human | 50616 | Details Get a Quote |
| IL22RA2 Knockout A-549 Cell Line | EDJ-KQ66471 | Human | 116379 | Details Get a Quote |
| IL22 Knockout HCT 116 Cell Line | EDJ-KQ73113 | Human | 50616 | Details Get a Quote |
| IL22RA2 Knockout HCT 116 Cell Line | EDJ-KQ74893 | Human | 116379 | Details Get a Quote |
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