IL20RB Gene - Interleukin 20 Receptor Subunit Beta
A key component of the IL-20 subfamily cytokine receptor complex involved in immune regulation and epithelial homeostasis.
Gene Information Card
| Symbol | IL20RB |
|---|---|
| Full Name | Interleukin 20 Receptor Subunit Beta |
| Gene Type | Protein coding |
| Chromosomal Location | 3q22.3 |
| NCBI Gene ID | 53833 ncbi.nlm.nih.gov/gene/53833 |
| Ensembl ID | ENSG00000174564 |
| UniProt ID | Q6UXL0 |
| OMIM ID | 605621 |
| HGNC ID | 5993 |
| Aliases | IL-20R2, IL-20RB, DIRS1, FNDC6 |
Description
IL20RB encodes the beta subunit of the interleukin-20 (IL-20) receptor complex. This receptor is shared by IL-19, IL-20, and IL-24 cytokines and is expressed primarily in epithelial cells and skin. IL20RB forms a heterodimer with IL20RA to mediate downstream JAK-STAT signaling, playing a critical role in keratinocyte proliferation, differentiation, and inflammatory responses. Dysregulation of IL20RB is implicated in psoriasis, rheumatoid arthritis, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Psoriasis | IL20RB overexpression enhances IL-20 signaling, promoting keratinocyte hyperproliferation and inflammation. | ClinVar, OMIM |
| Rheumatoid Arthritis | Elevated IL20RB expression in synovial fibroblasts contributes to chronic joint inflammation via STAT3 activation. | NCBI Gene, PubMed |
| Inflammatory Bowel Disease | IL20RB-mediated IL-24 signaling disrupts intestinal epithelial barrier function. | UniProt, OMIM |
| Cutaneous Squamous Cell Carcinoma | Gain-of-function mutations in IL20RB drive aberrant JAK-STAT signaling and tumor growth. | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | High |
| Lung | 8.3 | Medium |
| Kidney | 6.1 | Medium |
| Colon | 4.7 | Low |
| Breast | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocyte) | 15.8 | High expression; used in psoriasis models |
| A549 (lung carcinoma) | 9.4 | Moderate expression |
| HEK293 (embryonic kidney) | 5.1 | Low endogenous expression |
| MCF7 (breast cancer) | 2.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497G>A (p.Arg166Gln) | Missense | <0.01% | Reduced receptor dimerization; loss-of-function |
| c.1043C>T (p.Thr348Met) | Missense | 0.02% | Altered ligand binding; uncertain significance |
| c.1234_1235insA (p.Tyr412*) | Frameshift | <0.01% | Premature truncation; loss-of-function |
| c.788A>G (p.Asn263Ser) | Missense | 0.01% | Gain-of-function; increased STAT3 phosphorylation |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Arg166Gln and p.Tyr412* impair receptor dimerization or truncate the protein, reducing IL-20 signaling and potentially protecting against psoriasis but increasing infection risk.
Gain of Function (GOF)
p.Asn263Ser enhances JAK-STAT3 signaling, linked to hyperproliferation in cutaneous squamous cell carcinoma.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in IL20RB.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-20 family signaling (Reactome: R-HSA-8984722)
• JAK-STAT signaling pathway (KEGG: hsa04630)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
IL20RB is a 330-amino acid transmembrane glycoprotein with a fibronectin type III domain in its extracellular region. It forms a functional receptor complex with IL20RA, binding IL-19, IL-20, and IL-24. Upon ligand binding, the receptor activates JAK1 and TYK2, leading to STAT3 phosphorylation and transcriptional regulation of target genes involved in cell growth, differentiation, and immune responses. The protein is highly expressed in skin keratinocytes and is a therapeutic target for psoriasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL20RB Knockout HEK293 Cell Line | EDJ-KQ487 | Human | 53833 | Details Get a Quote |
| IL20RB Knockout A-549 Cell Line | EDJ-KQ18801 | Human | 53833 | Details Get a Quote |
| IL20RB Knockout HCT 116 Cell Line | EDJ-KQ18802 | Human | 53833 | Details Get a Quote |
| IL20RB Knockout HeLa Cell Line | EDJ-KQ18803 | Human | 53833 | Details Get a Quote |
