IL1R2
Interleukin 1 Receptor Type 2
Gene Information Card
| Symbol | IL1R2 |
|---|---|
| Full Name | Interleukin 1 Receptor Type 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 7850 ncbi.nlm.nih.gov/gene/7850 |
| Ensembl ID | ENSG00000115594 |
| UniProt ID | P27930 |
| OMIM ID | 147811 |
| HGNC ID | 5995 |
| Aliases | IL1RB, CD121b, IL-1R-2, IL-1RT-2 |
Description
IL1R2 encodes the interleukin 1 receptor type 2, a decoy receptor that binds interleukin 1 (IL-1) ligands without inducing intracellular signaling. It functions as a negative regulator of IL-1-mediated inflammation by sequestering IL-1α and IL-1β and preventing their interaction with the functional IL-1 receptor type 1 (IL1R1). The gene is located on chromosome 2q11.2 and is primarily expressed on immune cells, including monocytes, neutrophils, and B cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | IL1R2 decoy receptor downregulation leads to increased IL-1 signaling and joint inflammation | ClinVar, OMIM |
| Sepsis | Elevated soluble IL1R2 levels correlate with disease severity and mortality | NCBI Gene, PubMed |
| Inflammatory Bowel Disease | Altered IL1R2 expression contributes to dysregulated IL-1-mediated gut inflammation | OMIM, ClinVar |
| Atherosclerosis | IL1R2 modulates vascular inflammation by controlling IL-1 bioavailability | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole Blood | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Bone Marrow | 15.2 | Medium |
| Lymph Node | 9.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Monocytes | 18.7 | High expression |
| Neutrophils | 22.1 | High expression |
| B lymphocytes | 7.4 | Medium expression |
| THP-1 | 14.5 | Monocytic cell line |
| U937 | 11.2 | Histiocytic lymphoma line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Reduced protein expression |
| c.245C>T | nonsense | <0.01% | Premature truncation, loss of function |
| c.789G>A | missense | 0.02% | Altered ligand binding affinity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations that truncate the protein reduce decoy activity, increasing IL-1 signaling.
Gain of Function (GOF)
Not reported for IL1R2.
Dominant Negative (DN)
Not reported for IL1R2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interleukin-1 signaling (Reactome: R-HSA-446652)
• IL-1 family signaling (KEGG: hsa04620)
Protein Summary
IL1R2 is a 386-amino acid transmembrane glycoprotein with three extracellular immunoglobulin-like domains, a single transmembrane helix, and a short cytoplasmic tail lacking the TIR domain required for signaling. It exists in membrane-bound and soluble forms (sIL1R2). The soluble form is generated by proteolytic cleavage or alternative splicing and acts as a decoy to neutralize IL-1 in circulation. The protein is heavily N-glycosylated and expressed on the surface of immune cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL1R2 Knockout HEK293 Cell Line | EDJ-KQ6135 | Human | 7850 | Details Get a Quote |
| IL1R2 Knockout A-549 Cell Line | EDJ-KQ28607 | Human | 7850 | Details Get a Quote |
| IL1R2 Knockout HeLa Cell Line | EDJ-KQ54801 | Human | 7850 | Details Get a Quote |
| IL1R2 Knockout HCT 116 Cell Line | EDJ-KQ71759 | Human | 7850 | Details Get a Quote |
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