IL1F10 (Interleukin 1 Family Member 10)
A cytokine of the IL-1 family with anti-inflammatory properties
Gene Information Card
| Symbol | IL1F10 |
|---|---|
| Full Name | Interleukin 1 Family Member 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q14.1 |
| NCBI Gene ID | 84639 ncbi.nlm.nih.gov/gene/84639 |
| Ensembl ID | ENSG00000136695 |
| UniProt ID | Q8WWZ1 |
| OMIM ID | 609628 |
| HGNC ID | 16915 |
| Aliases | IL-38, FIL1-theta, IL1HY2, IL1-theta |
Description
IL1F10 encodes interleukin-38 (IL-38), a member of the interleukin-1 cytokine family. IL-38 binds to the IL-1 receptor accessory protein (IL1RAP) and the IL-36 receptor (IL-36R), functioning as an anti-inflammatory cytokine by inhibiting IL-36 signaling. It is expressed in skin, tonsils, and certain immune cells, and has been implicated in inflammatory and autoimmune diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid arthritis | IL-38 reduces IL-36-mediated inflammation by blocking IL-36R signaling | PMID: 25687188 |
| Psoriasis | IL-38 downregulation in psoriatic skin leads to increased IL-36-driven inflammation | PMID: 26014625 |
| Systemic lupus erythematosus | IL-38 levels correlate with disease activity and modulate cytokine production | PMID: 28264816 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 2.3 | Low |
| Tonsil | 1.8 | Low |
| Spleen | 1.2 | Low |
| Lung | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HaCaT (keratinocytes) | 1.5 | Constitutive expression |
| THP-1 (monocytes) | 0.8 | Induced by LPS |
| Jurkat (T cells) | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs3811058 | SNP | 0.15 (global) | Intronic; associated with altered IL-38 expression in autoimmune disease |
| rs3811059 | SNP | 0.10 (global) | Missense; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Not reported in COSMIC or ClinVar for IL1F10
Gain of Function (GOF)
Not reported in COSMIC or ClinVar for IL1F10
Dominant Negative (DN)
Not reported in COSMIC or ClinVar for IL1F10
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity | • interleukin-1 receptor binding |
| • immune response | • inflammatory response |
| • negative regulation of interleukin-6 production |
Pathways
• IL-1 family signaling
• IL-36 signaling pathway
Protein Summary
IL-38 is a 152-amino acid protein with a typical IL-1 family beta-trefoil fold. It lacks a signal peptide and is secreted via a non-classical pathway. IL-38 binds to IL-36R and IL1RAP, antagonizing IL-36-induced NF-κB and MAPK activation, thereby suppressing pro-inflammatory cytokine production.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL1F10 Knockout HEK293 Cell Line | EDJ-KQ10143 | Human | 84639 | Details Get a Quote |
| IL1F10 Knockout HeLa Cell Line | EDJ-KQ57626 | Human | 84639 | Details Get a Quote |
| IL1F10 Knockout A-549 Cell Line | EDJ-KQ66124 | Human | 84639 | Details Get a Quote |
| IL1F10 Knockout HCT 116 Cell Line | EDJ-KQ74549 | Human | 84639 | Details Get a Quote |
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