IL17F Gene
Interleukin 17F: A Key Cytokine in Immune and Inflammatory Responses
Gene Information Card
| Symbol | IL17F |
|---|---|
| Full Name | Interleukin 17F |
| Gene Type | protein-coding |
| Chromosomal Location | 6p12.2 |
| NCBI Gene ID | 112744 ncbi.nlm.nih.gov/gene/112744 |
| Ensembl ID | ENSG00000112115 |
| UniProt ID | Q96PD4 |
| OMIM ID | 606496 |
| HGNC ID | 16404 |
| Aliases | IL-17F, ML-1, ML1 |
Description
IL17F encodes interleukin 17F (IL-17F), a pro-inflammatory cytokine secreted by activated T cells, particularly Th17 cells. IL-17F signals through a receptor complex composed of IL-17RA and IL-17RC, inducing the production of other cytokines, chemokines, and antimicrobial peptides. It plays a critical role in host defense against extracellular bacteria and fungi and is implicated in the pathogenesis of autoimmune and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | IL17F variants may alter airway inflammation and Th17-mediated responses | ClinVar, NCBI |
| Psoriasis | IL17F contributes to keratinocyte activation and neutrophil recruitment in skin lesions | NCBI, OMIM |
| Inflammatory Bowel Disease (IBD) | IL17F polymorphisms associated with increased intestinal inflammation | NCBI, ClinVar |
| Rheumatoid Arthritis | IL17F promotes synovial inflammation and bone erosion | NCBI |
| Candidiasis | Loss-of-function IL17F mutations impair mucosal antifungal immunity | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.8 | Low |
| Spleen | 0.5 | Low |
| Thymus | 0.3 | Low |
| Small Intestine | 0.2 | Low |
| Colon | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Th17 cells | N/A | Primary source of IL17F expression |
| CD4+ T cells | N/A | Induced upon activation |
| NK cells | N/A | Minor expression |
| Neutrophils | N/A | Detected in some studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.His161Arg | Missense | Rare | Impaired receptor binding and reduced signaling (loss-of-function) |
| p.Gly65Arg | Missense | Rare | Reduced secretion and activity (loss-of-function) |
| p.Arg101Gln | Missense | Rare | Altered cytokine function (uncertain significance) |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.His161Arg and p.Gly65Arg reduce IL-17F secretion, receptor binding, or downstream signaling, impairing antifungal immunity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in IL17F.
Dominant Negative (DN)
Some IL17F missense variants may exert dominant-negative effects by interfering with wild-type IL-17F homodimer or heterodimer formation.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-17 signaling pathway (KEGG: hsa04657)
• Th17 cell differentiation (KEGG: hsa04659)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
IL-17F is a 163-amino acid cytokine that forms homodimers and heterodimers with IL-17A. It binds to the IL-17RA/IL-17RC receptor complex, activating NF-κB and MAPK pathways to induce pro-inflammatory gene expression. IL-17F is structurally similar to IL-17A but exhibits weaker signaling potency. It is essential for mucosal immunity against Candida and Staphylococcus species and is a therapeutic target in psoriasis and other inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL17F Knockout HEK293 Cell Line | EDJ-KQ7392 | Human | 112744 | Details Get a Quote |
| IL17F Knockout HeLa Cell Line | EDJ-KQ57896 | Human | 112744 | Details Get a Quote |
| IL17F Knockout A-549 Cell Line | EDJ-KQ66391 | Human | 112744 | Details Get a Quote |
| IL17F Knockout HCT 116 Cell Line | EDJ-KQ74816 | Human | 112744 | Details Get a Quote |
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