IL13RA1
Interleukin 13 Receptor Subunit Alpha 1
Gene Information Card
| Symbol | IL13RA1 |
|---|---|
| Full Name | Interleukin 13 Receptor Subunit Alpha 1 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq24 |
| NCBI Gene ID | 3597 ncbi.nlm.nih.gov/gene/3597 |
| Ensembl ID | ENSG00000131724 |
| UniProt ID | P78552 |
| OMIM ID | 300119 |
| HGNC ID | 5974 |
| Aliases | IL13R, IL13RA, NR4, CD213a1 |
Description
IL13RA1 encodes a subunit of the interleukin-13 receptor complex. This protein binds IL13 with low affinity but, upon heterodimerization with IL4R, forms a high-affinity receptor that mediates IL13 signaling. IL13RA1 is involved in allergic inflammation, asthma, fibrosis, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | IL13RA1 forms a receptor complex with IL4R to transduce IL13 signals, promoting airway hyperresponsiveness and mucus production. | ClinVar, OMIM |
| Allergic rhinitis | Enhanced IL13 signaling via IL13RA1 contributes to IgE production and eosinophilic inflammation. | OMIM |
| Pulmonary fibrosis | IL13RA1-mediated signaling drives fibroblast activation and collagen deposition. | NCBI Gene, OMIM |
| Hodgkin lymphoma | IL13RA1 overexpression supports autocrine IL13 growth loops in Reed-Sternberg cells. | COSMIC, NCBI Gene |
| Glioblastoma | IL13RA1 is overexpressed in glioblastoma; targeted therapies using IL13-PE38 immunotoxin are under investigation. | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Bone marrow | 6.7 | Low |
| Lymph node | 9.1 | Medium |
| Skin | 5.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 14.2 | High expression |
| HepG2 (hepatocellular carcinoma) | 7.8 | Medium expression |
| K562 (leukemia) | 4.5 | Low expression |
| MCF7 (breast cancer) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.110G>A (p.Arg37His) | Missense | <0.1% | Unknown functional impact; reported in ClinVar |
| c.457C>T (p.Arg153Trp) | Missense | <0.1% | May alter ligand binding; limited evidence |
| c.784A>G (p.Ile262Val) | Missense | 0.2% | Likely benign; population frequency |
| c.1021G>A (p.Glu341Lys) | Missense | <0.1% | Reported in COSMIC; somatic in cancer |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in IL13RA1.
Gain of Function (GOF)
No confirmed gain-of-function mutations; overexpression is observed in some cancers.
Dominant Negative (DN)
No dominant-negative mutations described for IL13RA1.
View complete mutation data：
Gene Ontology (GO)
| • interleukin-13 receptor activity | • interleukin-4 receptor activity |
| • cytokine receptor activity | • signal transduction |
| • cell surface receptor signaling pathway | • immune response |
Pathways
• IL13 signaling pathway
• IL4-mediated signaling events
• JAK-STAT signaling pathway
• Th2 differentiation pathway
• Asthma pathway
Protein Summary
IL13RA1 is a 427-amino acid transmembrane glycoprotein (UniProt P78552) with an extracellular domain containing a fibronectin type III domain. It binds IL13 with low affinity and, upon association with IL4R, forms a functional receptor that activates JAK1/TYK2 and STAT6. The protein is expressed in immune cells, lung, and various tumors. It is a target for therapeutic antibodies (e.g., lebrikizumab) and immunotoxins in cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IL13RA1 Knockout HEK293 Cell Line | EDJ-KQ483 | Human | 3597 | Details Get a Quote |
| IL13RA1 Knockout HeLa Cell Line | EDJ-KQ17948 | Human | 3597 | Details Get a Quote |
| IL13RA1 Knockout A-549 Cell Line | EDJ-KQ18795 | Human | 3597 | Details Get a Quote |
| IL13RA1 Knockout HCT 116 Cell Line | EDJ-KQ18796 | Human | 3597 | Details Get a Quote |
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