IKBIP: IKBKB Interacting Protein
A regulator of NF-κB signaling and potential tumor suppressor
Gene Information Card
| Symbol | IKBIP |
|---|---|
| Full Name | IKBKB Interacting Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 12q23.1 |
| NCBI Gene ID | 121457 ncbi.nlm.nih.gov/gene/121457 |
| Ensembl ID | ENSG00000150672 |
| UniProt ID | Q70UQ0 |
| OMIM ID | 616296 |
| HGNC ID | 29106 |
| Aliases | FLJ14668, KIAA1910 |
Description
IKBIP (IKBKB Interacting Protein) encodes a protein that interacts with IKBKB (IκB kinase beta), a key component of the NF-κB signaling pathway. The protein is involved in the regulation of NF-κB activation, potentially modulating inflammatory and immune responses. IKBIP has been implicated in cancer, where its expression may influence tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered IKBIP expression may dysregulate NF-κB signaling, promoting cell survival and proliferation. | NCBI Gene, COSMIC |
| Inflammatory disorders | Modulation of NF-κB pathway by IKBIP could affect inflammatory cytokine production. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.8 | Low expression |
| A549 | 6.5 | Low expression |
| MCF7 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% | Unknown functional impact |
| c.1234G>A (p.Gly412Ser) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • I-kappaB kinase/NF-kappaB signaling (GO:0007249) |
| • cytoplasm (GO:0005737) |
Pathways
• NF-kappa B signaling pathway (KEGG: hsa04064)
• TNF signaling pathway (KEGG: hsa04668)
Protein Summary
The IKBIP protein is a 648-amino acid polypeptide that interacts with IKBKB. It is localized in the cytoplasm and modulates NF-κB signaling. Its exact molecular function remains under investigation, but it is thought to act as a scaffold or regulator in the IKK complex.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IKBIP Knockout HEK293 Cell Line | EDJ-KQ8013 | Human | 121457 | Details Get a Quote |
| IKBIP Knockout A-549 Cell Line | EDJ-KQ33771 | Human | 121457 | Details Get a Quote |
| IKBIP Knockout HCT 116 Cell Line | EDJ-KQ33772 | Human | 121457 | Details Get a Quote |
| IKBIP Knockout HeLa Cell Line | EDJ-KQ33773 | Human | 121457 | Details Get a Quote |
