IGSF21
Immunoglobulin Superfamily Member 21
Gene Information Card
| Symbol | IGSF21 |
|---|---|
| Full Name | Immunoglobulin Superfamily Member 21 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 84988 ncbi.nlm.nih.gov/gene/84988 |
| Ensembl ID | ENSG00000162627 |
| UniProt ID | Q96ID5 |
| OMIM ID | 617619 |
| HGNC ID | 28995 |
| Aliases | CXorf36, PRO340, bA155J5.1 |
Description
IGSF21 (Immunoglobulin Superfamily Member 21) is a protein-coding gene located on chromosome 1p36.33. It encodes a member of the immunoglobulin superfamily, characterized by immunoglobulin-like domains. The protein is involved in cell adhesion and immune system processes. Expression is observed in various tissues, with notable levels in the brain and immune cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Lung | 3.1 | Low |
| Spleen | 2.8 | Low |
| Testis | 4.5 | Medium |
| Kidney | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.5 | Moderate expression |
| K562 | 1.2 | Low expression |
| HepG2 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • protein binding (GO:0005515) |
Pathways
• No specific pathways annotated
Protein Summary
The IGSF21 protein is a single-pass type I membrane protein containing immunoglobulin-like domains. It is predicted to play a role in cell-cell adhesion and immune modulation. The protein is localized to the plasma membrane and is expressed in multiple tissues, particularly in the brain and immune-related organs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGSF21 Knockout HEK293 Cell Line | EDJ-KQ10287 | Human | 84966 | Details Get a Quote |
| IGSF21 Knockout HeLa Cell Line | EDJ-KQ57688 | Human | 84966 | Details Get a Quote |
| IGSF21 Knockout A-549 Cell Line | EDJ-KQ66188 | Human | 84966 | Details Get a Quote |
| IGSF21 Knockout HCT 116 Cell Line | EDJ-KQ74613 | Human | 84966 | Details Get a Quote |
