IGIP (IgGFc-binding protein) Gene
Comprehensive gene card for IGIP, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | IGIP |
|---|---|
| Full Name | IgGFc-binding protein |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000113520 |
| UniProt ID | Q9Y6R7 |
| OMIM ID | 604864 |
| HGNC ID | 5959 |
| Aliases | FCGBP, Fc fragment of IgG binding protein |
Description
IGIP encodes the IgGFc-binding protein, a large mucin-like glycoprotein that binds to the Fc region of immunoglobulin G. It is involved in immune regulation and mucosal defense, and is expressed in various tissues including the gastrointestinal tract and respiratory epithelium.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | Altered expression of IGIP may disrupt mucosal immune homeostasis, contributing to chronic inflammation. | PMID: 23455675 |
| Colorectal Cancer | Overexpression of IGIP has been observed in colorectal tumors, potentially promoting immune evasion. | PMID: 25691885 |
| Asthma | IGIP expression in airway epithelium may modulate IgE-mediated responses. | PMID: 27541638 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 12.5 | Medium |
| Small Intestine | 10.2 | Medium |
| Lung | 8.7 | Medium |
| Stomach | 6.3 | Low |
| Esophagus | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 15.3 | Colorectal adenocarcinoma cell line |
| HT-29 | 12.8 | Colorectal adenocarcinoma cell line |
| A549 | 9.4 | Lung carcinoma cell line |
| HepG2 | 2.1 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.01% | p.Pro412Ser; uncertain significance |
| c.4567_4568insA | Frameshift | <0.01% | Predicted loss of function |
| c.7890G>A | Nonsense | <0.01% | p.Trp2630*; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for IGIP.
Dominant Negative (DN)
No dominant-negative mutations have been described for IGIP.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • protein binding (GO:0005515) |
| • IgG binding (GO:0019864) | • immune response (GO:0006955) |
Pathways
• Immune System (Reactome: R-HSA-168256)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
The IgGFc-binding protein is a large, secreted glycoprotein that binds to the Fc region of IgG antibodies. It is implicated in mucosal immunity and may play a role in modulating inflammatory responses. The protein is characterized by multiple von Willebrand factor type D domains and a mucin-like region.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGIP Knockout HEK293 Cell Line | EDJ-KQ13815 | Human | 492311 | Details Get a Quote |
| IGIP Knockout A-549 Cell Line | EDJ-KQ43636 | Human | 492311 | Details Get a Quote |
| IGIP Knockout HCT 116 Cell Line | EDJ-KQ43637 | Human | 492311 | Details Get a Quote |
| IGIP Knockout HeLa Cell Line | EDJ-KQ43638 | Human | 492311 | Details Get a Quote |
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