IGFBP7: Insulin Like Growth Factor Binding Protein 7
A secreted tumor suppressor and senescence-associated protein with roles in cancer, aging, and metabolic disorders.
Gene Information Card
| Symbol | IGFBP7 |
|---|---|
| Full Name | Insulin Like Growth Factor Binding Protein 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q12 |
| NCBI Gene ID | 3490 ncbi.nlm.nih.gov/gene/3490 |
| Ensembl ID | ENSG00000163453 |
| UniProt ID | Q16270 |
| OMIM ID | 602867 |
| HGNC ID | 5476 |
| Aliases | AGM, FSTL2, IGFBP-7, IGFBP-7v, MAC25, PSF, RAMSVES, TAF |
Description
IGFBP7 (Insulin Like Growth Factor Binding Protein 7) encodes a secreted protein that binds insulin-like growth factors (IGFs) with low affinity and regulates cell growth, senescence, and apoptosis. It functions as a tumor suppressor in multiple cancers and is implicated in aging, metabolic syndrome, and vascular diseases. The protein is also known as MAC25 and is a member of the IGFBP superfamily.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Loss of IGFBP7 expression via promoter hypermethylation reduces tumor suppression, promoting proliferation and invasion. | PMID: 19252506; COSMIC |
| Breast Cancer | Reduced IGFBP7 levels correlate with poor prognosis; re-expression induces senescence and apoptosis. | PMID: 17332331; NCBI Gene |
| Prostate Cancer | IGFBP7 downregulation is associated with aggressive disease; acts as a negative regulator of IGF signaling. | PMID: 20010872; OMIM |
| Type 2 Diabetes | IGFBP7 modulates insulin sensitivity and is elevated in serum of diabetic patients, linked to metabolic dysfunction. | PMID: 25687214; ClinVar |
| Aging/Senescence | IGFBP7 is a senescence-associated secretory phenotype (SASP) factor, upregulated in aged tissues. | PMID: 18762567; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Liver | 8.7 | Low |
| Kidney | 15.2 | Medium |
| Lung | 18.9 | Medium |
| Brain | 6.1 | Low |
| Colon | 22.4 | High |
| Breast | 14.5 | Medium |
| Prostate | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 16.3 | Cervical cancer cell line; moderate expression |
| MCF7 | 9.8 | Breast cancer cell line; low expression |
| HCT116 | 24.5 | Colorectal cancer cell line; high expression |
| A549 | 12.1 | Lung cancer cell line; medium expression |
| HEK293 | 18.7 | Embryonic kidney; high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; predicted loss of function |
| c.287G>A (p.Arg96His) | Missense | 0.2% | Unknown significance; reported in COSMIC |
| c.634C>T (p.Arg212*) | Nonsense | <0.1% | Truncating; loss of function |
| c.1015_1016insA | Frameshift | <0.1% | Frameshift; loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg212*, c.1015_1016insA) lead to truncated or degraded protein, reducing tumor suppressor activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described for IGFBP7.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Insulin-like growth factor (IGF) signaling pathway
• p53 signaling pathway
• Senescence-associated secretory phenotype (SASP)
Protein Summary
IGFBP7 is a 282-amino-acid secreted glycoprotein (UniProt Q16270) that binds IGFs with low affinity and insulin with high affinity. It contains an N-terminal IGFBP domain and a C-terminal Kazal-type serine protease inhibitor domain. The protein is involved in cell adhesion, growth regulation, and senescence. It is frequently silenced by promoter methylation in cancers, acting as a tumor suppressor. Post-translational modifications include glycosylation and proteolytic processing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGFBP7 Knockout HEK293 Cell Line | EDJ-KQ4983 | Human | 3490 | Details Get a Quote |
| IGFBP7 Knockout A-549 Cell Line | EDJ-KQ27870 | Human | 3490 | Details Get a Quote |
| IGFBP7 Knockout HeLa Cell Line | EDJ-KQ27871 | Human | 3490 | Details Get a Quote |
| IGFBP7 Knockout HCT 116 Cell Line | EDJ-KQ70583 | Human | 3490 | Details Get a Quote |
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