IGFBP5
Insulin Like Growth Factor Binding Protein 5
Gene Information Card
| Symbol | IGFBP5 |
|---|---|
| Full Name | Insulin Like Growth Factor Binding Protein 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 3488 ncbi.nlm.nih.gov/gene/3488 |
| Ensembl ID | ENSG00000115461 |
| UniProt ID | P24593 |
| OMIM ID | 146734 |
| HGNC ID | 5474 |
| Aliases | IBP5, IGFBP-5 |
Description
IGFBP5 encodes insulin-like growth factor binding protein 5, a member of the IGFBP family that modulates the actions of insulin-like growth factors (IGF-I and IGF-II) by binding to them with high affinity. This protein is involved in cell growth, differentiation, and apoptosis, and is expressed in various tissues including bone, kidney, and breast. It has both IGF-dependent and IGF-independent functions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoporosis | IGFBP5 modulates IGF bioavailability in bone, affecting osteoblast and osteoclast activity; altered expression linked to bone mineral density. | NCBI Gene, OMIM |
| Breast Cancer | IGFBP5 overexpression in breast cancer cells can promote or inhibit tumor growth depending on context; associated with poor prognosis in some studies. | NCBI Gene, COSMIC |
| Prostate Cancer | IGFBP5 expression is altered in prostate cancer; may influence IGF signaling and cell proliferation. | COSMIC, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.3 | Medium |
| Liver | 8.7 | Medium |
| Bone | 15.2 | High |
| Breast | 6.1 | Low |
| Lung | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 10.1 | IGFBP5 expression associated with hormone receptor status |
| PC3 (prostate cancer) | 7.8 | Moderate expression; linked to metastasis |
| HEK293 (embryonic kidney) | 14.5 | High baseline expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.200C>T | missense | <0.1% | Reported in COSMIC; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Insulin-like growth factor (IGF) signaling pathway
• PI3K-Akt signaling pathway
Protein Summary
IGFBP5 is a 252-amino acid secreted protein that binds IGF-I and IGF-II with high affinity, regulating their bioavailability and interaction with IGF receptors. It also has IGF-independent effects, including modulation of cell adhesion and apoptosis. The protein contains an N-terminal IGFBP domain and a C-terminal thyroglobulin type-1 domain. Post-translational modifications include phosphorylation and proteolytic cleavage.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGFBP5 Knockout HEK293 Cell Line | EDJ-KQ4979 | Human | 3488 | Details Get a Quote |
| IGFBP5 Knockout HeLa Cell Line | EDJ-KQ27867 | Human | 3488 | Details Get a Quote |
| IGFBP5 Knockout A-549 Cell Line | EDJ-KQ62096 | Human | 3488 | Details Get a Quote |
| IGFBP5 Knockout HCT 116 Cell Line | EDJ-KQ70582 | Human | 3488 | Details Get a Quote |
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