IGFBP2: Insulin Like Growth Factor Binding Protein 2
A key regulator of IGF bioavailability and signaling in growth, development, and cancer
Gene Information Card
| Symbol | IGFBP2 |
|---|---|
| Full Name | Insulin Like Growth Factor Binding Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 3485 ncbi.nlm.nih.gov/gene/3485 |
| Ensembl ID | ENSG00000115457 |
| UniProt ID | P18065 |
| OMIM ID | 146731 |
| HGNC ID | 5471 |
| Aliases | IBP2, IGF-BP53, BP2 |
Description
IGFBP2 encodes insulin-like growth factor binding protein 2, a member of the IGFBP family that binds insulin-like growth factors (IGF-I and IGF-II) with high affinity, modulating their bioavailability and interaction with IGF receptors. It plays roles in cell growth, migration, and survival, and is implicated in various cancers and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioblastoma | IGFBP2 overexpression promotes tumor cell invasion and proliferation via IGF-independent integrin signaling | PMID: 15930273 |
| Prostate Cancer | Elevated IGFBP2 levels correlate with disease progression and castration resistance | PMID: 16985006 |
| Ovarian Cancer | IGFBP2 upregulation in malignant ascites enhances tumor growth and angiogenesis | PMID: 17975017 |
| Type 2 Diabetes | IGFBP2 polymorphisms associated with insulin sensitivity and glucose homeostasis | PMID: 19584355 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Brain | 6.1 | Low |
| Prostate | 4.7 | Low |
| Adipose Tissue | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| MCF7 | 9.8 | Breast cancer cell line |
| A549 | 7.4 | Lung cancer cell line |
| HepG2 | 6.5 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500G>A (p.Arg167His) | Missense | <0.01% | Altered IGF binding affinity |
| c.763C>T (p.Arg255Trp) | Missense | <0.01% | Unknown functional effect |
| c.1-?_*?del | Deletion | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Deletions or nonsense mutations leading to reduced IGF binding or secretion
Gain of Function (GOF)
Overexpression or amplification in tumors enhancing oncogenic signaling
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• IGF-IGFBP axis (Reactome: R-HSA-381866)
• IGF1R signaling cascade (Reactome: R-HSA-2404192)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
IGFBP2 is a 36 kDa secreted protein containing an N-terminal IGF-binding domain, a linker region, and a C-terminal thyroglobulin type-1 domain. It modulates IGF activity by sequestering IGFs in the extracellular space, but also exerts IGF-independent effects via integrin receptor interactions, promoting cell adhesion and migration. Overexpression in multiple cancers correlates with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGFBP2 Knockout HEK293 Cell Line | EDJ-KQ4976 | Human | 3485 | Details Get a Quote |
| IGFBP2 Knockout HCT 116 Cell Line | EDJ-KQ26642 | Human | 3485 | Details Get a Quote |
| IGFBP2 Knockout A-549 Cell Line | EDJ-KQ27863 | Human | 3485 | Details Get a Quote |
| IGFBP2 Knockout HeLa Cell Line | EDJ-KQ27864 | Human | 3485 | Details Get a Quote |
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