IGF2BP2
Insulin Like Growth Factor 2 mRNA Binding Protein 2
Gene Information Card
| Symbol | IGF2BP2 |
|---|---|
| Full Name | Insulin Like Growth Factor 2 mRNA Binding Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.2 |
| NCBI Gene ID | 10644 ncbi.nlm.nih.gov/gene/10644 |
| Ensembl ID | ENSG00000173757 |
| UniProt ID | Q9Y6M1 |
| OMIM ID | 608289 |
| HGNC ID | 28866 |
| Aliases | IMP2, VICKZ2, p62, IGF2 mRNA-binding protein 2 |
Description
IGF2BP2 (Insulin Like Growth Factor 2 mRNA Binding Protein 2) encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein binds to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It is involved in RNA localization, stability, and translational control, playing roles in cell growth, metabolism, and development. Variants in IGF2BP2 have been associated with type 2 diabetes and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Type 2 Diabetes | Risk variants in IGF2BP2 are associated with impaired insulin secretion and beta-cell dysfunction. | GWAS studies (PMID: 17463246, 17463248) |
| Colorectal Cancer | Overexpression of IGF2BP2 promotes tumor growth and metastasis via enhanced IGF2 translation. | COSMIC and literature (PMID: 25691885) |
| Hepatocellular Carcinoma | IGF2BP2 upregulation correlates with poor prognosis and increased cell proliferation. | PMID: 28411370 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Liver | 15.2 | Medium |
| Colon | 10.1 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.7 | Cervical cancer cell line |
| HepG2 | 22.3 | Hepatocellular carcinoma cell line |
| MCF7 | 14.5 | Breast cancer cell line |
| K562 | 9.8 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs4402960 | SNP | ~30% in East Asian populations | Intronic variant associated with increased T2D risk |
| rs1470579 | SNP | ~25% in European populations | Intronic variant linked to T2D susceptibility |
| p.Gly71Arg | Missense | Rare | Reported in COSMIC for colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some variants may reduce RNA binding affinity.
Gain of Function (GOF)
Overexpression in cancers suggests oncogenic gain-of-function activity.
Dominant Negative (DN)
No evidence currently available.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • mRNA 3'-UTR binding |
| • translation regulator activity | • cytoplasmic stress granule |
| • regulation of translation |
Pathways
• IGF2 mRNA binding and translation
• mRNA surveillance pathway
• Regulation of insulin secretion
Protein Summary
IGF2BP2 is a 599-amino acid RNA-binding protein containing two RNA recognition motifs (RRMs) and four K-homology (KH) domains. It specifically binds to the 5' untranslated region of IGF2 mRNA, enhancing its translation. The protein localizes to the cytoplasm and stress granules, and is involved in mRNA transport and stability. Its dysregulation contributes to metabolic disorders and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGF2BP2 Knockout HEK293 Cell Line | EDJ-KQ102 | Human | 10644 | Details Get a Quote |
| IGF2BP2 Knockout A-549 Cell Line | EDJ-KQ43623 | Human | 10644 | Details Get a Quote |
| IGF2BP2 Knockout HCT 116 Cell Line | EDJ-KQ43624 | Human | 10644 | Details Get a Quote |
| IGF2BP2 Knockout HeLa Cell Line | EDJ-KQ43625 | Human | 10644 | Details Get a Quote |
| IGF2BP2 Knockout 786-O Cell Line | EDJ-KZ292 | Human | 10644 | Details Get a Quote |
| IGF2BP2 Knockout HSC-3 Cell Line | EDJ-KZ294 | Human | 10644 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
