IGF2BP1
Insulin Like Growth Factor 2 mRNA Binding Protein 1
Gene Information Card
| Symbol | IGF2BP1 |
|---|---|
| Full Name | Insulin Like Growth Factor 2 mRNA Binding Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.32 |
| NCBI Gene ID | 10642 ncbi.nlm.nih.gov/gene/10642 |
| Ensembl ID | ENSG00000159212 |
| UniProt ID | Q9NZI8 |
| OMIM ID | 608259 |
| HGNC ID | 28866 |
| Aliases | IMP1, CRD-BP, VICKZ1, ZBP1 |
Description
IGF2BP1 (Insulin Like Growth Factor 2 mRNA Binding Protein 1) encodes a member of the IGF-II mRNA-binding protein family. The protein binds to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It is involved in post-transcriptional regulation, including mRNA localization, stability, and translational control. IGF2BP1 is highly expressed during embryonic development and is re-expressed in various cancers, where it promotes cell proliferation, migration, and invasion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | IGF2BP1 overexpression stabilizes IGF2 and other oncogenic mRNAs, promoting tumor growth | PMID: 21804562 |
| Colorectal cancer | IGF2BP1 enhances MYC and CD44 mRNA stability, driving metastasis | PMID: 26921328 |
| Breast cancer | IGF2BP1 binds to and stabilizes beta-catenin mRNA, activating Wnt signaling | PMID: 22939622 |
| Lung cancer | IGF2BP1 upregulation correlates with poor prognosis and increased invasion | PMID: 25451967 |
| Ovarian cancer | IGF2BP1 promotes cell proliferation via IGF2 mRNA stabilization | PMID: 23541953 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Placenta | 8.7 | Medium |
| Liver | 1.2 | Low |
| Lung | 0.8 | Low |
| Brain | 0.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.6 | Hepatocellular carcinoma cell line |
| HCT116 | 18.2 | Colorectal carcinoma cell line |
| MCF7 | 9.4 | Breast cancer cell line |
| A549 | 7.8 | Lung carcinoma cell line |
| HeLa | 5.1 | Cervical carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | <0.1% (COSMIC) | Unknown functional effect |
| c.567_568insA | Frameshift | <0.1% (COSMIC) | Predicted loss of function |
| c.890G>A | Missense | <0.1% (COSMIC) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IGF2 mRNA stabilization and translation
• Wnt signaling pathway (via beta-catenin mRNA stabilization)
• MYC mRNA stability regulation
• CD44 mRNA stability regulation
Protein Summary
IGF2BP1 is a 577-amino acid RNA-binding protein containing two RNA recognition motifs (RRMs) and four hnRNP K homology (KH) domains. It binds to specific mRNA targets, including IGF2, MYC, CD44, and beta-catenin, regulating their stability, localization, and translation. The protein is predominantly cytoplasmic and localizes to stress granules and P-bodies. IGF2BP1 is critical for embryonic development and is frequently upregulated in cancers, where it acts as an oncogene by enhancing the expression of growth-promoting and metastatic genes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IGF2BP1 Knockout HEK293 Cell Line | EDJ-KQ17881 | Human | 10642 | Details Get a Quote |
| IGF2BP1 Knockout A-375 Cell Line | EDJ-KQ18109 | Human | 10642 | Details Get a Quote |
| IGF2BP1 Knockout A-549 Cell Line | EDJ-KQ18366 | Human | 10642 | Details Get a Quote |
| IGF2BP1 Knockout HeLa Cell Line | EDJ-KQ43622 | Human | 10642 | Details Get a Quote |
| IGF2BP1 Knockout HCT 116 Cell Line | EDJ-KQ72391 | Human | 10642 | Details Get a Quote |
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