IFNW1: Interferon Omega 1
A type I interferon cytokine with antiviral and immunomodulatory functions
Gene Information Card
| Symbol | IFNW1 |
|---|---|
| Full Name | Interferon Omega 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3467 ncbi.nlm.nih.gov/gene/3467 |
| Ensembl ID | ENSG00000185338 |
| UniProt ID | P05000 |
| OMIM ID | 147553 |
| HGNC ID | 5436 |
| Aliases | IFNW, IFN-omega 1 |
Description
IFNW1 encodes interferon omega 1, a type I interferon cytokine produced in response to viral and microbial infections. It binds to the type I interferon receptor (IFNAR1/IFNAR2) complex, activating JAK-STAT signaling to induce an antiviral state, modulate immune responses, and inhibit cell proliferation. IFNW1 is expressed in leukocytes and has overlapping but distinct activities compared to other type I interferons.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Viral infections (e.g., influenza, SARS-CoV-2) | IFNW1 induces antiviral gene expression via IFNAR signaling | NCBI Gene, UniProt |
| Autoimmune disorders (e.g., systemic lupus erythematosus) | Dysregulated type I interferon signaling contributes to autoimmunity | OMIM, ClinVar |
| Cancer (e.g., melanoma, leukemia) | IFNW1 can inhibit tumor cell proliferation; used in experimental therapies | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole blood | 0.4 | Low |
| Spleen | 0.2 | Low |
| Lung | 0.1 | Low |
| Bone marrow | 0.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Low baseline expression |
| K562 | 0.2 | Low baseline expression |
| THP-1 | 0.5 | Inducible by viral stimuli |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional impact |
| c.100C>T | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:R-HSA-913531~Interferon Signaling
• REACT:R-HSA-909733~Type I Interferon Induction and Signaling
Protein Summary
Interferon omega 1 is a 195-amino-acid secreted cytokine with a molecular weight of approximately 22 kDa. It contains a signal peptide (residues 1-23) and a mature interferon domain. The protein adopts a typical alpha-helical cytokine fold and is glycosylated. It exerts antiviral, antiproliferative, and immunomodulatory effects through binding to the IFNAR1/IFNAR2 receptor complex.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNW1 Knockout HEK293 Cell Line | EDJ-KQ130 | Human | 3467 | Details Get a Quote |
| IFNW1 Knockout HeLa Cell Line | EDJ-KQ53622 | Human | 3467 | Details Get a Quote |
| IFNW1 Knockout A-549 Cell Line | EDJ-KQ62092 | Human | 3467 | Details Get a Quote |
| IFNW1 Knockout HCT 116 Cell Line | EDJ-KQ70576 | Human | 3467 | Details Get a Quote |
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