IFNE Gene - Interferon Epsilon
A type I interferon with roles in antiviral and antitumor immunity
Gene Information Card
| Symbol | IFNE |
|---|---|
| Full Name | Interferon Epsilon |
| Gene Type | Protein coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 338376 ncbi.nlm.nih.gov/gene/338376 |
| Ensembl ID | ENSG00000185338 |
| UniProt ID | Q86WN2 |
| OMIM ID | 614444 |
| HGNC ID | 18675 |
| Aliases | IFN-E, IFNE1 |
Description
IFNE encodes interferon epsilon, a type I interferon cytokine involved in innate immune responses against viral and bacterial pathogens. It is constitutively expressed in epithelial tissues, particularly the female reproductive tract, and plays a role in mucosal immunity. IFNE also exhibits antitumor activity and is regulated by hormones and inflammatory signals.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Viral Infections | IFNE provides antiviral protection in mucosal epithelia by inducing interferon-stimulated genes | NCBI Gene, UniProt |
| Bacterial Infections | IFNE contributes to host defense against bacterial pathogens in reproductive tissues | UniProt |
| Cancer | IFNE has antitumor effects; dysregulation may contribute to tumor progression | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Endometrium | 0.6 | Low |
| Cervix | 0.5 | Low |
| Vagina | 0.4 | Low |
| Skin | 0.3 | Low |
| Lung | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.1 | Cervical cancer cell line |
| A549 | 0.1 | Lung carcinoma cell line |
| MCF7 | 0.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in major databases | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity (GO:0005125) | • extracellular space (GO:0005615) |
| • immune response (GO:0006955) | • type I interferon signaling pathway (GO:0060337) |
| • innate immune response (GO:0045087) |
Pathways
• Type I interferon signaling pathway (Reactome: R-HSA-909733)
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
Protein Summary
Interferon epsilon is a secreted type I interferon of approximately 20 kDa. It binds to the IFNAR1/IFNAR2 receptor complex, activating JAK-STAT signaling and inducing expression of interferon-stimulated genes. It is constitutively expressed in epithelial tissues, especially the female reproductive tract, and is regulated by hormones. It has antiviral, antibacterial, and antitumor activities.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNE Knockout HEK293 Cell Line | EDJ-KQ474 | Human | 338376 | Details Get a Quote |
| IFNE Knockout HCT 116 Cell Line | EDJ-KQ18008 | Human | 338376 | Details Get a Quote |
| IFNE Knockout A-549 Cell Line | EDJ-KQ18780 | Human | 338376 | Details Get a Quote |
| IFNE Knockout HeLa Cell Line | EDJ-KQ18781 | Human | 338376 | Details Get a Quote |
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