IFNA7: Interferon Alpha 7
A cytokine gene involved in antiviral defense and immune regulation
Gene Information Card
| Symbol | IFNA7 |
|---|---|
| Full Name | Interferon Alpha 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3444 ncbi.nlm.nih.gov/gene/3444 |
| Ensembl ID | ENSG00000120235 |
| UniProt ID | P01571 |
| OMIM ID | 147580 |
| HGNC ID | 5422 |
| Aliases | IFNA-J, IFN-alpha-J, interferon alpha-7 |
Description
IFNA7 encodes a member of the type I interferon family, interferon alpha 7, a cytokine with potent antiviral, antiproliferative, and immunomodulatory activities. It is secreted by leukocytes in response to viral infection and binds to the interferon alpha/beta receptor (IFNAR) to activate JAK-STAT signaling, leading to expression of interferon-stimulated genes (ISGs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C Virus Infection | IFNA7 polymorphisms may influence response to interferon-based therapy | NCBI Gene, ClinVar |
| Systemic Lupus Erythematosus | Altered interferon alpha signaling contributes to autoimmune pathology | OMIM, NCBI |
| Viral Infections (general) | IFNA7 mediates innate antiviral immunity through ISG induction | UniProt, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.8 | Low |
| Lung | 0.5 | Low |
| Whole Blood | 0.3 | Low |
| Lymph Node | 0.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low baseline expression |
| K562 | 0.1 | Very low expression |
| HepG2 | 0.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10108980 | SNP | Not reported in COSMIC | May affect interferon response |
| rs1061237 | SNP | Not reported in COSMIC | Associated with hepatitis C treatment outcome |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function variants in COSMIC or ClinVar.
Dominant Negative (DN)
No confirmed dominant-negative variants in COSMIC or ClinVar.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• JAK-STAT signaling pathway (KEGG: hsa04630)
Protein Summary
Interferon alpha 7 (IFNA7) is a 189-amino-acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It belongs to the type I interferon family and shares structural homology with other interferon alpha subtypes. The protein forms a five-helix bundle and binds to the IFNAR1/IFNAR2 receptor complex, activating STAT1/STAT2 transcription factors to induce antiviral and immunomodulatory genes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA7 Knockout HEK293 Cell Line | EDJ-KQ50379 | Human | 3444 | Details Get a Quote |
| IFNA7 Knockout HeLa Cell Line | EDJ-KQ53611 | Human | 3444 | Details Get a Quote |
| IFNA7 Knockout A-549 Cell Line | EDJ-KQ62081 | Human | 3444 | Details Get a Quote |
| IFNA7 Knockout HCT 116 Cell Line | EDJ-KQ70565 | Human | 3444 | Details Get a Quote |
