IFNA6: Interferon Alpha 6
A cytokine gene involved in antiviral immunity and immune regulation
Gene Information Card
| Symbol | IFNA6 |
|---|---|
| Full Name | Interferon Alpha 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3443 ncbi.nlm.nih.gov/gene/3443 |
| Ensembl ID | ENSG00000120235 |
| UniProt ID | P05013 |
| OMIM ID | 147566 |
| HGNC ID | 5422 |
| Aliases | IFNA6, IFN-alpha-6, interferon alpha-6 |
Description
IFNA6 (Interferon Alpha 6) is a protein-coding gene that belongs to the type I interferon family. It encodes a cytokine with potent antiviral, antiproliferative, and immunomodulatory activities. The protein is secreted by cells in response to viral infections and other stimuli, binding to the type I interferon receptor (IFNAR) to activate the JAK-STAT signaling pathway, leading to the expression of interferon-stimulated genes (ISGs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C Virus Infection | IFNA6 polymorphisms influence treatment response to interferon-based therapy | NCBI Gene, ClinVar |
| Systemic Lupus Erythematosus | Altered interferon alpha signaling contributes to autoimmune pathogenesis | NCBI Gene, OMIM |
| Viral Infections (general) | IFNA6 mediates antiviral defense through ISG induction | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.8 | Low |
| Lung | 0.5 | Low |
| Whole Blood | 0.3 | Low |
| Lymph Node | 0.6 | Low |
| Bone Marrow | 0.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low baseline expression |
| HeLa | 0.1 | Low baseline expression |
| THP-1 | 0.5 | Inducible by viral mimetics |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10108980 | SNP | 0.15 (global) | Associated with altered interferon response |
| rs12979860 | SNP | 0.30 (global) | Linked to hepatitis C treatment outcome |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04630: JAK-STAT signaling pathway
• hsa04612: Antigen processing and presentation
• hsa05164: Influenza A
• hsa05168: Herpes simplex infection
Protein Summary
Interferon alpha-6 (IFNA6) is a 189-amino acid protein (signal peptide: 1-23; mature chain: 24-189) with a molecular weight of approximately 21.6 kDa. It is a member of the type I interferon family, characterized by a conserved alpha-helical structure. The protein is secreted and binds to the IFNAR1/IFNAR2 receptor complex, activating the JAK-STAT pathway to induce antiviral and immunomodulatory genes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA6 Knockout HEK293 Cell Line | EDJ-KQ2017 | Human | 3443 | Details Get a Quote |
| IFNA6 Knockout HeLa Cell Line | EDJ-KQ53610 | Human | 3443 | Details Get a Quote |
| IFNA6 Knockout A-549 Cell Line | EDJ-KQ62080 | Human | 3443 | Details Get a Quote |
| IFNA6 Knockout HCT 116 Cell Line | EDJ-KQ70564 | Human | 3443 | Details Get a Quote |
