IFNA5: Interferon Alpha-5 Gene
Cytokine gene involved in antiviral immunity and cancer biology
Gene Information Card
| Symbol | IFNA5 |
|---|---|
| Full Name | Interferon Alpha 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3446 ncbi.nlm.nih.gov/gene/3446 |
| Ensembl ID | ENSG00000147885 |
| UniProt ID | P01569 |
| OMIM ID | 147565 |
| HGNC ID | 5424 |
| Aliases | IFN-alpha-5, INFA5, leIF G |
Description
IFNA5 encodes a member of the type I interferon family, interferon alpha-5, which is secreted by immune cells in response to viral infection. This cytokine binds to the IFNAR receptor complex, activating JAK-STAT signaling to induce an antiviral state, inhibit cell proliferation, and modulate immune responses. IFNA5 is part of a cluster of interferon alpha genes on chromosome 9p21.3.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C virus infection | Reduced IFNA5 expression impairs antiviral response; therapeutic IFN-alpha used | ClinVar, PMID: 25428589 |
| Systemic lupus erythematosus | Dysregulated type I interferon signaling including IFNA5 contributes to autoimmunity | OMIM, PMID: 29739914 |
| Chronic myeloid leukemia | IFNA5 is part of interferon-based therapy; response linked to genetic variants | COSMIC, PMID: 21844182 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 1.2 | Low |
| Lymph node | 0.8 | Low |
| Whole blood | 0.5 | Not detected |
| Bone marrow | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Low baseline expression |
| K562 | 0.2 | Chronic myeloid leukemia cell line |
| HepG2 | 0.3 | Hepatocellular carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Alters start codon; potential loss of function |
| c.167C>T | missense | <0.01% | p.Thr56Ile; unknown significance |
| c.334G>A | missense | <0.01% | p.Val112Met; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:R-HSA-913531~Interferon alpha/beta signaling
• REACT:R-HSA-168928~JAK-STAT signaling pathway
• REACT:R-HSA-909733~Interferon gamma signaling
Protein Summary
Interferon alpha-5 is a 189-amino-acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It forms a five-helix bundle typical of type I interferons. The protein binds to the IFNAR1/IFNAR2 receptor complex, initiating phosphorylation of STAT1 and STAT2, leading to transcription of interferon-stimulated genes (ISGs). IFNA5 exhibits antiviral, antiproliferative, and immunomodulatory activities.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA5 Knockout HEK293 Cell Line | EDJ-KQ4970 | Human | 3442 | Details Get a Quote |
| IFNA5 Knockout HeLa Cell Line | EDJ-KQ53609 | Human | 3442 | Details Get a Quote |
| IFNA5 Knockout A-549 Cell Line | EDJ-KQ62079 | Human | 3442 | Details Get a Quote |
| IFNA5 Knockout HCT 116 Cell Line | EDJ-KQ70563 | Human | 3442 | Details Get a Quote |
