IFNA17: Interferon Alpha 17
A cytokine gene involved in antiviral defense and immune regulation
Gene Information Card
| Symbol | IFNA17 |
|---|---|
| Full Name | Interferon Alpha 17 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3451 ncbi.nlm.nih.gov/gene/3451 |
| Ensembl ID | ENSG00000140937 |
| UniProt ID | P01571 |
| OMIM ID | 147583 |
| HGNC ID | 5422 |
| Aliases | IFNA, IFN-alpha-17, leIF K, interferon alpha-17 |
Description
IFNA17 (Interferon Alpha 17) is a protein-coding gene located on chromosome 9p21.3. It belongs to the type I interferon family and encodes a cytokine with potent antiviral, antiproliferative, and immunomodulatory activities. The protein is secreted by leukocytes and binds to the interferon alpha/beta receptor (IFNAR), activating JAK-STAT signaling to induce an antiviral state in cells.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C virus infection | IFNA17 polymorphisms influence interferon response and treatment outcome | PMID: 15858117 |
| Systemic lupus erythematosus | Genetic variants in IFNA17 may alter interferon production and autoimmune risk | PMID: 19838197 |
| Chronic hepatitis B | IFNA17 variants associated with response to interferon therapy | PMID: 16885437 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.6 | Low |
| Lung | 0.3 | Low |
| Whole blood | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| Peripheral blood mononuclear cells (PBMCs) | 0.2 | Induced upon viral stimulation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs9290910 | SNP | 0.15 (global) | Associated with altered interferon response |
| rs3761382 | SNP | 0.10 (global) | May affect protein function |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in IFNA17.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity (GO:0005125) | • extracellular space (GO:0005615) |
| • immune response (GO:0006955) | • JAK-STAT cascade (GO:0007259) |
| • negative regulation of viral genome replication (GO:0045071) |
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• JAK-STAT signaling pathway (KEGG: hsa04630)
Protein Summary
Interferon alpha-17 (IFNA17) is a 189-amino acid protein (UniProt P01571) with a signal peptide (residues 1-23) and a mature chain (24-189). It belongs to the type I interferon family and shares structural homology with other interferon alphas. The protein is secreted and binds to the IFNAR1/IFNAR2 receptor complex, activating STAT1/STAT2 transcription factors to induce interferon-stimulated genes (ISGs).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA17 Knockout HEK293 Cell Line | EDJ-KQ50382 | Human | 3451 | Details Get a Quote |
| IFNA17 Knockout HeLa Cell Line | EDJ-KQ53617 | Human | 3451 | Details Get a Quote |
| IFNA17 Knockout A-549 Cell Line | EDJ-KQ62087 | Human | 3451 | Details Get a Quote |
| IFNA17 Knockout HCT 116 Cell Line | EDJ-KQ70571 | Human | 3451 | Details Get a Quote |
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