IFNA16: Interferon Alpha 16
Cytokine gene involved in antiviral and immunomodulatory signaling
Gene Information Card
| Symbol | IFNA16 |
|---|---|
| Full Name | Interferon Alpha 16 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3449 ncbi.nlm.nih.gov/gene/3449 |
| Ensembl ID | ENSG00000147885 |
| UniProt ID | P05015 |
| OMIM ID | 147583 |
| HGNC ID | 5423 |
| Aliases | IFNA, IFN-alpha-16, interferon alpha-16 |
Description
IFNA16 encodes a member of the type I interferon family, interferon alpha 16, which is secreted by leukocytes and plays a critical role in antiviral defense, immunomodulation, and cell growth regulation. The protein binds to the IFNAR1/IFNAR2 receptor complex to activate JAK-STAT signaling and induce expression of interferon-stimulated genes (ISGs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C virus infection | IFNA16 polymorphisms may influence treatment response to interferon-based therapy | PMID: 20686651 |
| Systemic lupus erythematosus | Type I interferon pathway dysregulation, including IFNA16, contributes to autoimmune pathology | PMID: 25658027 |
| COVID-19 | Type I interferons including IFNA16 are involved in antiviral response against SARS-CoV-2 | PMID: 32579887 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.8 | Low |
| Lung | 0.5 | Low |
| Whole blood | 0.3 | Low |
| Lymph node | 0.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low baseline expression |
| THP-1 | 1.5 | Induced by viral stimulation |
| Jurkat | 0.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.167C>T | synonymous | <0.01% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity (GO:0005125) | • extracellular space (GO:0005615) |
| • type I interferon signaling pathway (GO:0060337) | • innate immune response (GO:0045087) |
Pathways
• R-HSA-913531 (Interferon alpha/beta signaling)
• R-HSA-168256 (Immune System)
• R-HSA-1280215 (Cytokine Signaling in Immune system)
Protein Summary
Interferon alpha 16 is a 189-amino-acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It contains a conserved interferon alpha family domain and forms a five-helix bundle structure. The protein is produced primarily by plasmacytoid dendritic cells and monocytes in response to viral infection.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA16 Knockout HEK293 Cell Line | EDJ-KQ50381 | Human | 3449 | Details Get a Quote |
| IFNA16 Knockout HeLa Cell Line | EDJ-KQ53616 | Human | 3449 | Details Get a Quote |
| IFNA16 Knockout A-549 Cell Line | EDJ-KQ62086 | Human | 3449 | Details Get a Quote |
| IFNA16 Knockout HCT 116 Cell Line | EDJ-KQ70570 | Human | 3449 | Details Get a Quote |
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