IFNA14: Interferon Alpha 14
A type I interferon cytokine involved in antiviral and immunomodulatory signaling
Gene Information Card
| Symbol | IFNA14 |
|---|---|
| Full Name | Interferon Alpha 14 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3448 ncbi.nlm.nih.gov/gene/3448 |
| Ensembl ID | ENSG00000188379 |
| UniProt ID | P01574 |
| OMIM ID | 147572 |
| HGNC ID | 5426 |
| Aliases | IFNA14, IFN-alpha-14, LeIF H |
Description
IFNA14 encodes a member of the type I interferon family, interferon alpha 14. This cytokine is secreted by cells in response to viral infection and binds to the interferon alpha/beta receptor (IFNAR) to activate JAK-STAT signaling, leading to antiviral, antiproliferative, and immunomodulatory effects.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C virus infection | IFNA14 is part of the endogenous interferon response; polymorphisms may influence treatment response | ClinVar, PMID: 19064627 |
| Systemic lupus erythematosus | Type I interferon pathway dysregulation, including IFNA14 overexpression, contributes to autoimmunity | OMIM 152700, PMID: 23291587 |
| COVID-19 severity | Reduced type I interferon activity, including IFNA14, associated with severe disease | ClinVar, PMID: 32972995 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.3 | Low |
| Lung | 0.2 | Low |
| Whole blood | 0.1 | Low |
| Lymph node | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.1 | Low baseline expression |
| A549 | 0.2 | Inducible by viral infection |
| THP-1 | 0.3 | Inducible by LPS or virus |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.100C>T | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome R-HSA-909733)
• Cytokine-cytokine receptor interaction (KEGG hsa04060)
• JAK-STAT signaling pathway (KEGG hsa04630)
Protein Summary
Interferon alpha 14 (IFNA14) is a 189-amino acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It belongs to the type I interferon family and shares structural homology with other IFN-alpha subtypes. The protein binds to IFNAR1/IFNAR2 receptor complex, activating STAT1/STAT2 transcription factors to induce interferon-stimulated genes (ISGs).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA14 Knockout HEK293 Cell Line | EDJ-KQ469 | Human | 3448 | Details Get a Quote |
| IFNA14 Knockout HeLa Cell Line | EDJ-KQ53615 | Human | 3448 | Details Get a Quote |
| IFNA14 Knockout A-549 Cell Line | EDJ-KQ62085 | Human | 3448 | Details Get a Quote |
| IFNA14 Knockout HCT 116 Cell Line | EDJ-KQ70569 | Human | 3448 | Details Get a Quote |
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