IFNA13: Interferon Alpha 13
Cytokine with antiviral and immunomodulatory functions
Gene Information Card
| Symbol | IFNA13 |
|---|---|
| Full Name | Interferon Alpha 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3447 ncbi.nlm.nih.gov/gene/3447 |
| Ensembl ID | ENSG00000233816 |
| UniProt ID | P01562 |
| OMIM ID | 147580 |
| HGNC ID | 5418 |
| Aliases | IFNA1, IFN-alpha-13, leIF D |
Description
IFNA13 encodes a member of the type I interferon family, interferon alpha 13. This cytokine is produced primarily in response to viral infections and exhibits antiviral, antiproliferative, and immunomodulatory activities. It binds to the interferon alpha/beta receptor (IFNAR) to activate JAK-STAT signaling, leading to expression of interferon-stimulated genes (ISGs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C | IFNA13 variants may influence response to interferon-based therapy | PMID: 19064627 |
| Systemic Lupus Erythematosus | Type I interferon pathway dysregulation | PMID: 21833088 |
| COVID-19 | Type I interferon deficiency associated with severe disease | PMID: 32972995 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.4 | Low |
| Lung | 0.2 | Low |
| Whole Blood | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Low baseline expression |
| HeLa | 0.2 | Inducible by viral infection |
| THP-1 | 0.3 | Inducible by LPS |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.166C>T | Nonsense | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity | • type I interferon receptor binding |
| • innate immune response | • defense response to virus |
| • JAK-STAT cascade |
Pathways
• Interferon alpha/beta signaling
• Cytokine-cytokine receptor interaction
• RIG-I-like receptor signaling
Protein Summary
Interferon alpha 13 is a 189-amino acid secreted cytokine with a signal peptide (residues 1-23) and a mature protein (24-189). It contains five alpha helices and two disulfide bonds (Cys1-Cys98, Cys29-Cys138) essential for structural stability and receptor binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA13 Knockout HEK293 Cell Line | EDJ-KQ50380 | Human | 3447 | Details Get a Quote |
| IFNA13 Knockout HeLa Cell Line | EDJ-KQ53614 | Human | 3447 | Details Get a Quote |
| IFNA13 Knockout A-549 Cell Line | EDJ-KQ62084 | Human | 3447 | Details Get a Quote |
| IFNA13 Knockout HCT 116 Cell Line | EDJ-KQ70568 | Human | 3447 | Details Get a Quote |
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