IFNA10: Interferon Alpha 10
A type I interferon cytokine involved in antiviral and immunomodulatory signaling
Gene Information Card
| Symbol | IFNA10 |
|---|---|
| Full Name | Interferon Alpha 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 3446 ncbi.nlm.nih.gov/gene/3446 |
| Ensembl ID | ENSG00000186832 |
| UniProt ID | P01566 |
| OMIM ID | 147580 |
| HGNC ID | 5419 |
| Aliases | IFN-alpha10, IFN-alphaC, leIF A |
Description
IFNA10 (Interferon Alpha 10) is a protein-coding gene belonging to the type I interferon family. The encoded protein is a cytokine with potent antiviral, antiproliferative, and immunomodulatory activities. It is secreted by cells in response to viral infection and binds to the interferon alpha/beta receptor (IFNAR) to activate JAK-STAT signaling, leading to expression of interferon-stimulated genes (ISGs).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatitis C Virus Infection | IFNA10 is part of the endogenous interferon response; exogenous recombinant IFNA10 is used therapeutically to inhibit viral replication | NCBI Gene, ClinVar |
| Systemic Lupus Erythematosus | Dysregulated type I interferon signaling including IFNA10 contributes to autoimmune pathology | OMIM, PubMed |
| COVID-19 | Type I interferons including IFNA10 are critical for early antiviral defense; genetic variants may influence disease severity | ClinVar, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 0.8 | Low |
| Spleen | 0.6 | Low |
| Lung | 0.3 | Not detected |
| Whole blood | 0.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.1 | Very low baseline expression; inducible by viral infection |
| HeLa | 0.2 | Inducible by poly(I:C) or viral infection |
| THP-1 | 0.5 | Monocytic cell line; inducible by LPS or virus |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | Rare | Potential loss of function; not well characterized |
| c.167C>T | missense | Rare | p.Thr56Ile; unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in IFNA10.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Cytokine signaling in immune system (Reactome: R-HSA-1280215)
• JAK-STAT signaling pathway (KEGG: hsa04630)
Protein Summary
Interferon alpha-10 (IFNA10) is a 189-amino-acid secreted cytokine with a signal peptide (residues 1-23) and a mature chain (24-189). It contains five alpha-helices and two disulfide bonds (Cys1-Cys98, Cys29-Cys138) characteristic of type I interferons. The protein binds to the IFNAR1/IFNAR2 receptor complex, activating JAK1 and TYK2 kinases, which phosphorylate STAT1 and STAT2, leading to ISGF3 complex formation and transcription of interferon-stimulated genes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFNA10 Knockout HEK293 Cell Line | EDJ-KQ4972 | Human | 3446 | Details Get a Quote |
| IFNA10 Knockout HeLa Cell Line | EDJ-KQ53613 | Human | 3446 | Details Get a Quote |
| IFNA10 Knockout A-549 Cell Line | EDJ-KQ62083 | Human | 3446 | Details Get a Quote |
| IFNA10 Knockout HCT 116 Cell Line | EDJ-KQ70567 | Human | 3446 | Details Get a Quote |
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