IFITM10
Interferon-Induced Transmembrane Protein 10
Gene Information Card
| Symbol | IFITM10 |
|---|---|
| Full Name | Interferon Induced Transmembrane Protein 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 402682 ncbi.nlm.nih.gov/gene/402682 |
| Ensembl ID | ENSG00000180228 |
| UniProt ID | A6NGB0 |
| OMIM ID | 617482 |
| HGNC ID | 33876 |
| Aliases | MGC16169, MGC26733 |
Description
IFITM10 (Interferon Induced Transmembrane Protein 10) is a protein-coding gene located on chromosome 11p15.5. It belongs to the IFITM family, which is involved in interferon-mediated antiviral responses and cellular signaling. The gene encodes a small transmembrane protein with potential roles in immune modulation and cell proliferation. Expression data suggest broad tissue distribution, with highest levels in lymphoid tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.3 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 9.5 | Medium |
| Lung | 6.2 | Low |
| Kidney | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.7 | Moderate expression |
| HeLa | 6.4 | Low expression |
| K562 | 11.2 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) | • protein binding (GO:0005515) |
Pathways
• Interferon signaling (Reactome: R-HSA-913531)
Protein Summary
IFITM10 is a 133-amino acid transmembrane protein with a molecular weight of approximately 15 kDa. It contains a conserved CD225 domain characteristic of the IFITM family. The protein localizes to cellular membranes and is thought to modulate interferon responses, though its precise biochemical function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFITM10 Knockout HEK293 Cell Line | EDJ-KQ11675 | Human | 402778 | Details Get a Quote |
| IFITM10 Knockout HeLa Cell Line | EDJ-KQ60329 | Human | 402778 | Details Get a Quote |
| IFITM10 Knockout A-549 Cell Line | EDJ-KQ68796 | Human | 402778 | Details Get a Quote |
| IFITM10 Knockout HCT 116 Cell Line | EDJ-KQ77159 | Human | 402778 | Details Get a Quote |
