IFIT3: Interferon-Induced Protein with Tetratricopeptide Repeats 3
A key antiviral effector and innate immune modulator
Gene Information Card
| Symbol | IFIT3 |
|---|---|
| Full Name | Interferon Induced Protein with Tetratricopeptide Repeats 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q23.31 |
| NCBI Gene ID | 3437 ncbi.nlm.nih.gov/gene/3437 |
| Ensembl ID | ENSG00000119917 |
| UniProt ID | O14879 |
| OMIM ID | 604650 |
| HGNC ID | 5411 |
| Aliases | CIG-49, GARG-49, IFIT4, ISG60, RIG-G |
Description
IFIT3 encodes a member of the interferon-induced tetratricopeptide repeat (IFIT) family. The protein contains multiple tetratricopeptide repeats that mediate protein-protein interactions. IFIT3 is strongly induced by type I interferons and plays a critical role in antiviral innate immunity by inhibiting viral replication and translation. It also modulates cellular signaling pathways, including NF-κB and IRF3, and is implicated in cancer progression and autoimmune diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | IFIT3 overexpression contributes to interferon signature and immune dysregulation | ClinVar, PMID: 25658027 |
| Viral infections (e.g., influenza, SARS-CoV-2) | IFIT3 restricts viral RNA translation and replication through binding to viral proteins | NCBI Gene, PMID: 21957124 |
| Hepatocellular carcinoma | IFIT3 promotes tumor growth via NF-κB activation and anti-apoptotic signaling | COSMIC, PMID: 29395073 |
| Breast cancer | High IFIT3 expression correlates with poor prognosis and chemoresistance | COSMIC, PMID: 30530642 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 45.2 | High |
| Spleen | 38.7 | High |
| Lung | 12.1 | Medium |
| Liver | 8.5 | Medium |
| Brain | 0.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 62.3 | IFN-α/β stimulation increases expression |
| A549 | 48.9 | Viral infection induces upregulation |
| HepG2 | 15.4 | Basal expression; induced by IFN |
| MCF7 | 22.1 | High in aggressive subtypes |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional effect |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Reported in cancer samples (COSMIC) |
| c.1240A>G (p.Ile414Val) | Missense | <0.01% | ClinVar: uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations; overexpression in cancer suggests oncogenic role.
Dominant Negative (DN)
Not described for IFIT3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Antiviral mechanism by IFN-stimulated genes (Reactome: R-HSA-1169410)
• RIG-I/MDA5 mediated induction of IFN-alpha/beta (Reactome: R-HSA-168928)
Protein Summary
IFIT3 is a 56 kDa protein with multiple tetratricopeptide repeats that facilitate interactions with viral proteins and host factors. It inhibits viral translation by binding to the eukaryotic initiation factor 3 (eIF3) complex and sequestering viral RNA. IFIT3 also enhances interferon signaling by stabilizing IRF3 and promoting NF-κB activation. Its expression is tightly regulated by interferons and is often dysregulated in cancers and autoimmune disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFIT3 Knockout HEK293 Cell Line | EDJ-KQ4974 | Human | 3437 | Details Get a Quote |
| IFIT3 Knockout A-549 Cell Line | EDJ-KQ27858 | Human | 3437 | Details Get a Quote |
| IFIT3 Knockout HCT 116 Cell Line | EDJ-KQ27859 | Human | 3437 | Details Get a Quote |
| IFIT3 Knockout HeLa Cell Line | EDJ-KQ27860 | Human | 3437 | Details Get a Quote |
