IFIT2 (Interferon-Induced Protein With Tetratricopeptide Repeats 2)
A key antiviral and pro-apoptotic interferon-stimulated gene involved in innate immunity and cancer biology.
Gene Information Card
| Symbol | IFIT2 |
|---|---|
| Full Name | Interferon-Induced Protein With Tetratricopeptide Repeats 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.31 |
| NCBI Gene ID | 3433 ncbi.nlm.nih.gov/gene/3433 |
| Ensembl ID | ENSG00000119922 |
| UniProt ID | P09913 |
| OMIM ID | 146694 |
| HGNC ID | 5409 |
| Aliases | ISG54, IFI54, GARG-39, cig42 |
Description
IFIT2 encodes a protein belonging to the interferon-induced protein with tetratricopeptide repeats (IFIT) family. It is strongly induced by type I interferons (IFN-α/β), viral infection, and double-stranded RNA. IFIT2 plays a critical role in innate immune defense by inhibiting viral replication and translation, and it also promotes apoptosis in response to various stimuli. It is involved in cell proliferation, migration, and immune modulation, with implications in cancer and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Viral infections (e.g., influenza, vesicular stomatitis virus) | IFIT2 inhibits viral protein synthesis by binding to viral RNA and interfering with translation initiation; also promotes apoptosis of infected cells. | Experimental studies in mice and cell lines (NCBI Gene, UniProt) |
| Cancer (e.g., hepatocellular carcinoma, breast cancer, lung cancer) | IFIT2 acts as a tumor suppressor in some contexts by inducing apoptosis and inhibiting cell proliferation and migration; expression is often downregulated in tumors. | Multiple studies (COSMIC, PubMed via NCBI) |
| Inflammatory diseases (e.g., rheumatoid arthritis) | IFIT2 modulates inflammatory cytokine production and immune cell function, potentially affecting disease severity. | Limited evidence (UniProt, NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 8.2 | Low |
| Spleen | 6.5 | Low |
| Liver | 4.3 | Low |
| Blood | 3.1 | Not detected |
| Brain | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa (cervical cancer) | 5.0 | Induced by IFN treatment |
| A549 (lung carcinoma) | 4.5 | Induced by IFN and viral infection |
| HepG2 (liver cancer) | 3.8 | Low basal expression |
| MCF7 (breast cancer) | 2.9 | Low basal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112C>T (p.Arg38Trp) | Missense | 0.01% (gnomAD) | Potential loss of function; affects protein stability |
| c.454G>A (p.Val152Met) | Missense | 0.005% (gnomAD) | Unknown; possibly benign |
| c.789delC (p.Pro264LeufsTer5) | Frameshift | Rare | Loss of function; truncated protein |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in IFIT2 are associated with impaired antiviral response and reduced apoptosis, potentially increasing susceptibility to viral infections and cancer.
Gain of Function (GOF)
Gain-of-function mutations are not well documented; overexpression of wild-type IFIT2 is generally tumor-suppressive.
Dominant Negative (DN)
No dominant-negative mutations have been reported for IFIT2.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • protein binding |
| • translation initiation factor activity | • immune response |
| • defense response to virus | • apoptotic process |
| • negative regulation of viral genome replication | • positive regulation of apoptotic process |
| • cellular response to interferon-beta | • cytoplasm |
| • cytosol |
Pathways
• Interferon signaling (R-HSA-913531)
• Antiviral mechanism by IFN-stimulated genes (R-HSA-1169408)
• Apoptosis (R-HSA-109581)
Protein Summary
IFIT2 is a 54 kDa protein composed of tetratricopeptide repeat (TPR) domains that mediate protein-protein interactions. It is primarily cytoplasmic and is induced by interferons. IFIT2 binds to viral RNA and inhibits translation initiation, thereby suppressing viral replication. It also interacts with cellular proteins to promote apoptosis and modulate immune responses. Its expression is often downregulated in various cancers, suggesting a tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFIT2 Knockout HEK293 Cell Line | EDJ-KQ4968 | Human | 3433 | Details Get a Quote |
| IFIT2 Knockout A-549 Cell Line | EDJ-KQ27850 | Human | 3433 | Details Get a Quote |
| IFIT2 Knockout HeLa Cell Line | EDJ-KQ27851 | Human | 3433 | Details Get a Quote |
| IFIT2 Knockout HCT 116 Cell Line | EDJ-KQ70559 | Human | 3433 | Details Get a Quote |
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