IFIT1B: Interferon-Induced Protein with Tetratricopeptide Repeats 1B
A key antiviral effector in the innate immune response to viral infection
Gene Information Card
| Symbol | IFIT1B |
|---|---|
| Full Name | Interferon Induced Protein with Tetratricopeptide Repeats 1B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q23.31 |
| NCBI Gene ID | 439996 ncbi.nlm.nih.gov/gene/439996 |
| Ensembl ID | ENSG00000185742 |
| UniProt ID | Q5VZK9 |
| OMIM ID | 614929 |
| HGNC ID | 26799 |
| Aliases | IFIT1L, IFIT1B, ISG56B |
Description
IFIT1B (Interferon Induced Protein with Tetratricopeptide Repeats 1B) is a member of the IFIT family of interferon-stimulated genes. It encodes a protein containing multiple tetratricopeptide repeats (TPR) that mediate protein-protein interactions. IFIT1B is induced by type I interferons and plays a role in the innate immune response by recognizing and binding viral RNA, thereby inhibiting viral replication and translation. It is closely related to IFIT1 (ISG56) but has distinct RNA-binding specificity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Viral infections (e.g., influenza, flavivirus) | IFIT1B binds viral RNA lacking 2'-O-methylation, inhibiting viral translation and replication | Experimental evidence from cell-based assays and animal models |
| Systemic lupus erythematosus (SLE) | Dysregulated interferon signaling may alter IFIT1B expression, contributing to autoimmune pathology | Association studies and transcriptomic profiling |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Small intestine | 6.7 | Low |
| Liver | 4.2 | Low |
| Whole blood | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.0 | High expression after IFN stimulation |
| HeLa (cervical carcinoma) | 10.2 | Moderate expression after IFN stimulation |
| HEK293 (embryonic kidney) | 7.5 | Low basal, induced by IFN |
| THP-1 (monocytic leukemia) | 5.0 | Induced by IFN and viral infection |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • double-stranded RNA binding |
| • translation initiation factor activity | • cytoplasm |
| • innate immune response | • response to virus |
| • negative regulation of viral genome replication |
Pathways
• Interferon alpha/beta signaling
• RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
• Antiviral mechanism by IFN-stimulated genes
Protein Summary
The IFIT1B protein (UniProt Q5VZK9) contains multiple tetratricopeptide repeats (TPR) that form a superhelical structure for binding viral RNA. It specifically recognizes RNA lacking 2'-O-methylation at the 5' cap, a feature of many viral transcripts. By sequestering viral RNA, IFIT1B inhibits translation initiation and suppresses viral replication. The protein is predominantly cytoplasmic and is rapidly induced upon interferon stimulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFIT1B Knockout HEK293 Cell Line | EDJ-KQ13800 | Human | 439996 | Details Get a Quote |
| IFIT1B Knockout HeLa Cell Line | EDJ-KQ60373 | Human | 439996 | Details Get a Quote |
| IFIT1B Knockout A-549 Cell Line | EDJ-KQ68840 | Human | 439996 | Details Get a Quote |
| IFIT1B Knockout HCT 116 Cell Line | EDJ-KQ77204 | Human | 439996 | Details Get a Quote |
