IFI27L2: Interferon Alpha-Inducible Protein 27 Like 2
A member of the IFI27 family involved in interferon response and potential roles in cancer and immune regulation.
Gene Information Card
| Symbol | IFI27L2 |
|---|---|
| Full Name | Interferon Alpha-Inducible Protein 27 Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.12 |
| NCBI Gene ID | 83982 ncbi.nlm.nih.gov/gene/83982 |
| Ensembl ID | ENSG00000100811 |
| UniProt ID | Q9H0X4 |
| OMIM ID | 618675 |
| HGNC ID | 25090 |
| Aliases | ISG12(b), FAM14B |
Description
IFI27L2 (Interferon Alpha-Inducible Protein 27 Like 2) is a protein-coding gene belonging to the IFI27 family. It is induced by type I interferons and is involved in the innate immune response. The gene is located on chromosome 14q32.12 and encodes a small hydrophobic protein that localizes to the endoplasmic reticulum and mitochondria. IFI27L2 has been implicated in apoptosis, cell proliferation, and viral defense. Its expression is dysregulated in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of IFI27L2 may promote cell proliferation and resistance to apoptosis via interferon signaling pathways. | PubMed: 23455478 |
| Hepatocellular Carcinoma | IFI27L2 is upregulated and associated with poor prognosis; may modulate immune evasion. | PubMed: 25636874 |
| Systemic Lupus Erythematosus | IFI27L2 is part of the interferon signature gene set, contributing to autoimmune pathology. | PubMed: 19838197 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Liver | 6.1 | Low |
| Breast | 4.7 | Low |
| Whole Blood | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast Cancer) | 15.2 | High expression |
| HepG2 (Liver Cancer) | 9.8 | Moderate expression |
| A549 (Lung Cancer) | 7.4 | Moderate expression |
| K562 (Leukemia) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% (gnomAD) | Potential loss of start codon; effect unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% (gnomAD) | Rare variant; functional impact not characterized |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in IFI27L2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in IFI27L2.
Dominant Negative (DN)
No dominant-negative mutations reported in IFI27L2.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrion (GO:0005739) | • endoplasmic reticulum (GO:0005783) |
| • identical protein binding (GO:0042802) | • type I interferon signaling pathway (GO:0060337) |
| • apoptotic process (GO:0006915) |
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Cytokine Signaling in Immune system (Reactome: R-HSA-1280215)
Protein Summary
IFI27L2 encodes a small hydrophobic protein of approximately 12 kDa, belonging to the IFI27 family. The protein is localized to the endoplasmic reticulum and mitochondria and is strongly induced by type I interferons. It is involved in the regulation of apoptosis, cell proliferation, and antiviral responses. Structural predictions indicate a transmembrane domain, suggesting a role in membrane-associated signaling. The protein is expressed in various tissues and is upregulated in several cancers, where it may contribute to tumor progression and immune modulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFI27L2 Knockout HEK293 Cell Line | EDJ-KQ9131 | Human | 83982 | Details Get a Quote |
| IFI27L2 Knockout A-549 Cell Line | EDJ-KQ36858 | Human | 83982 | Details Get a Quote |
| IFI27L2 Knockout HCT 116 Cell Line | EDJ-KQ36860 | Human | 83982 | Details Get a Quote |
| IFI27L2 Knockout HeLa Cell Line | EDJ-KQ36861 | Human | 83982 | Details Get a Quote |
