IFI27 (Interferon Alpha Inducible Protein 27)
A key interferon-stimulated gene involved in antiviral response, apoptosis, and cancer biology.
Gene Information Card
| Symbol | IFI27 |
|---|---|
| Full Name | Interferon Alpha Inducible Protein 27 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q32.12 |
| NCBI Gene ID | 3429 ncbi.nlm.nih.gov/gene/3429 |
| Ensembl ID | ENSG00000165949 |
| UniProt ID | Q9Y6K1 |
| OMIM ID | 603569 |
| HGNC ID | 5397 |
| Aliases | ISG12, FAM14D, P27, IFI27A |
Description
IFI27 (Interferon Alpha Inducible Protein 27) is a small, interferon-stimulated gene that encodes a protein localized to the mitochondria and endoplasmic reticulum. It is strongly induced by type I interferons and plays roles in antiviral defense, apoptosis, and cell cycle regulation. Overexpression is observed in various cancers and inflammatory conditions, making it a potential biomarker.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic Lupus Erythematosus | IFI27 is upregulated in response to type I interferons, contributing to the interferon signature in SLE. | NCBI Gene, OMIM |
| Psoriasis | Increased IFI27 expression in lesional skin correlates with interferon-driven inflammation. | NCBI Gene, OMIM |
| Breast Cancer | High IFI27 expression is associated with poor prognosis and resistance to chemotherapy. | COSMIC, NCBI Gene |
| Viral Infections (e.g., Hepatitis C) | IFI27 is induced by interferon therapy and may influence viral clearance. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 15.7 | Medium |
| Skin | 22.1 | High |
| Whole Blood | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast Cancer) | 18.4 | Interferon treatment increases expression |
| HepG2 (Liver Cancer) | 9.8 | Basal expression; induced by IFN-alpha |
| A549 (Lung Cancer) | 6.5 | Moderate expression |
| HaCaT (Keratinocyte) | 25.3 | High baseline; further induced by IFN-gamma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional impact |
| c.85C>T | Synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
• Cytokine Signaling in Immune system (Reactome: R-HSA-1280215)
• Apoptosis (KEGG: hsa04210)
Protein Summary
IFI27 is a 12 kDa protein (also known as ISG12) that localizes to mitochondria and ER. It is strongly induced by type I interferons and participates in antiviral responses by promoting apoptosis of infected cells. The protein can also modulate cell cycle progression and is implicated in cancer progression and autoimmune diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IFI27 Knockout HEK293 Cell Line | EDJ-KQ3076 | Human | 3429 | Details Get a Quote |
| IFI27L1 Knockout HEK293 Cell Line | EDJ-KQ8153 | Human | 122509 | Details Get a Quote |
| IFI27L2 Knockout HEK293 Cell Line | EDJ-KQ9131 | Human | 83982 | Details Get a Quote |
| IFI27L1 Knockout A-549 Cell Line | EDJ-KQ34058 | Human | 122509 | Details Get a Quote |
| IFI27L1 Knockout HCT 116 Cell Line | EDJ-KQ34059 | Human | 122509 | Details Get a Quote |
| IFI27L1 Knockout HeLa Cell Line | EDJ-KQ34060 | Human | 122509 | Details Get a Quote |
| IFI27 Knockout A-549 Cell Line | EDJ-KQ24363 | Human | 3429 | Details Get a Quote |
| IFI27 Knockout HCT 116 Cell Line | EDJ-KQ24364 | Human | 3429 | Details Get a Quote |
| IFI27 Knockout HeLa Cell Line | EDJ-KQ24365 | Human | 3429 | Details Get a Quote |
| IFI27L2 Knockout A-549 Cell Line | EDJ-KQ36858 | Human | 83982 | Details Get a Quote |
| IFI27L2 Knockout HCT 116 Cell Line | EDJ-KQ36860 | Human | 83982 | Details Get a Quote |
| IFI27L2 Knockout HeLa Cell Line | EDJ-KQ36861 | Human | 83982 | Details Get a Quote |
