IER5L
Immediate Early Response 5 Like
Gene Information Card
| Symbol | IER5L |
|---|---|
| Full Name | Immediate Early Response 5 Like |
| Gene Type | Protein coding |
| Chromosomal Location | 9q34.13 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q5T9L3 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37296 |
| Aliases | FLJ45256, MGC16384 |
Description
IER5L (Immediate Early Response 5 Like) is a protein-coding gene located on chromosome 9q34.13. It is a member of the immediate early response gene family, which is involved in cellular responses to stress and growth signals. The exact biological function of IER5L is not fully characterized, but it is thought to play a role in cell proliferation and differentiation. Expression data suggest broad tissue distribution with highest levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Medium |
| Testis | 6.5 | Medium |
| Lung | 3.1 | Low |
| Liver | 2.0 | Low |
| Kidney | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Moderate expression |
| HeLa | 3.2 | Low expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • No GO terms assigned |
Pathways
• No known pathways
Protein Summary
The IER5L protein (UniProt Q5T9L3) is a 244-amino acid polypeptide with no characterized domains. Its function remains largely unknown, but sequence similarity suggests it may be involved in immediate early response signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IER5L Knockout HEK293 Cell Line | EDJ-KQ13057 | Human | 389792 | Details Get a Quote |
| IER5L Knockout A-549 Cell Line | EDJ-KQ43597 | Human | 389792 | Details Get a Quote |
| IER5L Knockout HCT 116 Cell Line | EDJ-KQ43599 | Human | 389792 | Details Get a Quote |
| IER5L Knockout HeLa Cell Line | EDJ-KQ43600 | Human | 389792 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
