IER5: Immediate Early Response 5 Gene
A stress-responsive gene involved in cell cycle regulation and tumor suppression
Gene Information Card
| Symbol | IER5 |
|---|---|
| Full Name | Immediate Early Response 5 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q25.3 |
| NCBI Gene ID | 51278 ncbi.nlm.nih.gov/gene/51278 |
| Ensembl ID | ENSG00000162761 |
| UniProt ID | Q9H7Z7 |
| OMIM ID | 609447 |
| HGNC ID | 28823 |
| Aliases | SBBI48, IER5, MGC12966 |
Description
IER5 (Immediate Early Response 5) is a protein-coding gene that encodes a stress-responsive transcription factor. It is rapidly induced by various stimuli including growth factors, DNA damage, and cellular stress. IER5 plays a role in cell cycle regulation, particularly in G2/M checkpoint control, and has been implicated in tumor suppression. The protein localizes to the nucleus and can modulate the expression of target genes involved in apoptosis and proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | IER5 downregulation may promote cell proliferation and resistance to apoptosis; reduced expression correlates with poor prognosis. | NCBI Gene, COSMIC |
| Colorectal Cancer | IER5 expression is frequently reduced; loss of function may contribute to tumor progression via dysregulated cell cycle. | COSMIC, ClinVar |
| Lung Cancer | Mutations and altered expression of IER5 have been observed; potential role in chemoresistance. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Lymph Node | 10.2 | Medium |
| Spleen | 9.8 | Medium |
| Testis | 8.1 | Low |
| Brain | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression in embryonic kidney cells |
| HeLa | 11.2 | Moderate expression in cervical cancer cells |
| MCF7 | 6.5 | Low expression in breast cancer cells |
| A549 | 5.8 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.1% | Unknown functional effect; reported in COSMIC |
| c.421C>T (p.Arg141Trp) | Missense | <0.1% | Potential loss of function; observed in colorectal cancer |
| c.538_539insA | Frameshift | <0.1% | Predicted loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
No gain-of-function mutations have been reported for IER5.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for IER5.
View complete mutation data：
Gene Ontology (GO)
| • nucleus | • DNA-binding transcription factor activity |
| • regulation of cell cycle | • response to stress |
| • apoptotic process | • negative regulation of cell proliferation |
Pathways
• p53 signaling pathway
• Cellular response to stress
• G2/M DNA damage checkpoint
Protein Summary
IER5 is a 38 kDa nuclear protein containing a basic leucine zipper (bZIP) domain. It functions as a transcription factor that binds to DNA and regulates the expression of genes involved in cell cycle arrest and apoptosis. The protein is rapidly induced in response to DNA damage and other stresses, and it contributes to the maintenance of genomic stability by promoting G2/M checkpoint activation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| IER5 Knockout HEK293 Cell Line | EDJ-KQ11011 | Human | 51278 | Details Get a Quote |
| IER5L Knockout HEK293 Cell Line | EDJ-KQ13057 | Human | 389792 | Details Get a Quote |
| IER5 Knockout A-549 Cell Line | EDJ-KQ38884 | Human | 51278 | Details Get a Quote |
| IER5 Knockout HCT 116 Cell Line | EDJ-KQ38885 | Human | 51278 | Details Get a Quote |
| IER5 Knockout HeLa Cell Line | EDJ-KQ38886 | Human | 51278 | Details Get a Quote |
| IER5L Knockout A-549 Cell Line | EDJ-KQ43597 | Human | 389792 | Details Get a Quote |
| IER5L Knockout HCT 116 Cell Line | EDJ-KQ43599 | Human | 389792 | Details Get a Quote |
| IER5L Knockout HeLa Cell Line | EDJ-KQ43600 | Human | 389792 | Details Get a Quote |
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