ICAM1: Intercellular Adhesion Molecule 1
A key mediator of leukocyte adhesion and immune response, implicated in inflammatory diseases and cancer.
Gene Information Card
| Symbol | ICAM1 |
|---|---|
| Full Name | Intercellular Adhesion Molecule 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 3383 ncbi.nlm.nih.gov/gene/3383 |
| Ensembl ID | ENSG00000090339 |
| UniProt ID | P05362 |
| OMIM ID | 147840 |
| HGNC ID | 5344 |
| Aliases | CD54, BB2, P3.58 |
Description
ICAM1 (Intercellular Adhesion Molecule 1) is a cell surface glycoprotein that mediates adhesion between leukocytes and endothelial cells, playing a critical role in immune surveillance, inflammation, and transendothelial migration. It is a member of the immunoglobulin superfamily and binds to integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). ICAM1 expression is upregulated by pro-inflammatory cytokines (e.g., TNF-alpha, IL-1) and is implicated in various inflammatory and autoimmune diseases, as well as cancer metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | ICAM1 facilitates leukocyte adhesion to synovial endothelium, promoting joint inflammation. | ClinVar, OMIM |
| Atherosclerosis | Upregulated ICAM1 on endothelial cells recruits monocytes, contributing to plaque formation. | NCBI Gene, OMIM |
| Asthma | ICAM1 mediates eosinophil and T-cell adhesion to airway epithelium, exacerbating inflammation. | OMIM, ClinVar |
| Melanoma | ICAM1 expression on tumor cells promotes adhesion to endothelium, aiding metastasis. | COSMIC, NCBI Gene |
| Multiple Sclerosis | ICAM1 is involved in lymphocyte trafficking across the blood-brain barrier. | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 15.3 | Medium |
| Lymph node | 18.7 | High |
| Bone marrow | 9.8 | Low |
| Heart | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 45.2 | High baseline; induced by TNF-alpha |
| THP-1 (monocyte) | 22.1 | Moderate; upregulated by LPS |
| A549 (lung epithelial) | 8.5 | Low; inducible by IL-1 |
| Jurkat (T-cell) | 3.4 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs5498 (K469E) | Missense | 0.35 (global) | Alters ICAM1 binding affinity; associated with inflammatory disease risk |
| rs1799969 (G241R) | Missense | 0.02 | Rare; may affect integrin interaction |
| rs5030382 (intronic) | Intronic | 0.15 | Linked to altered expression in autoimmune conditions |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in ICAM1; homozygous knockout in mice is viable but shows impaired immune responses.
Gain of Function (GOF)
Gain-of-function is not established; overexpression in tumors is associated with metastasis.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • GO:0007155 - cell adhesion | • GO:0005178 - integrin binding |
| • GO:0005886 - plasma membrane | • GO:0006955 - immune response |
| • GO:0050900 - leukocyte migration |
Pathways
• Leukocyte transendothelial migration (KEGG: hsa04670)
• Cell adhesion molecules (CAMs) (KEGG: hsa04514)
• NF-kappa B signaling pathway (KEGG: hsa04064)
Protein Summary
ICAM1 is a 532-amino-acid type I transmembrane glycoprotein with five immunoglobulin-like domains in its extracellular region. It binds integrins LFA-1 and Mac-1, mediating leukocyte adhesion and migration. The protein is heavily glycosylated and expressed on endothelial cells, immune cells, and epithelial cells. Its cytoplasmic tail interacts with the cytoskeleton via alpha-actinin and other adaptors, facilitating signaling. ICAM1 is also a receptor for rhinoviruses and Plasmodium falciparum-infected erythrocytes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ICAM1 Knockout HEK293 Cell Line | EDJ-KQ93 | Human | 3383 | Details Get a Quote |
| TICAM1 Knockout HEK293 Cell Line | EDJ-KQ593 | Human | 148022 | Details Get a Quote |
| TICAM1 Knockout HeLa Cell Line | EDJ-KQ18035 | Human | 148022 | Details Get a Quote |
| TICAM1 Knockout A-549 Cell Line | EDC07592 | Human | 148022 | Details Get a Quote |
| TICAM1 Knockout HCT 116 Cell Line | EDJ-KQ19030 | Human | 148022 | Details Get a Quote |
| ICAM1 Knockout HCT 116 Cell Line | EDJ-KQ21079 | Human | 3383 | Details Get a Quote |
| ICAM1 Knockout HeLa Cell Line | EDJ-KQ21080 | Human | 3383 | Details Get a Quote |
| ICAM1 Knockout A-549 Cell Line | EDJ-KQ26288 | Human | 3383 | Details Get a Quote |
| ICAM1 Knockout Calu-1 Cell Line | EDJ-KZ288 | Human | 3383 | Details Get a Quote |
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