HYCC1: Hydroxycarboxylic Acid Receptor 1
A G protein-coupled receptor involved in metabolic regulation and potential therapeutic target for metabolic disorders.
Gene Information Card
| Symbol | HYCC1 |
|---|---|
| Full Name | Hydroxycarboxylic Acid Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 442428 ncbi.nlm.nih.gov/gene/442428 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q8TDV0 |
| OMIM ID | 606823 |
| HGNC ID | 4532 |
| Aliases | GPR81, HCA1, FKSG80 |
Description
HYCC1 (hydroxycarboxylic acid receptor 1) encodes a G protein-coupled receptor that is activated by lactate and other hydroxycarboxylic acids. It plays a role in metabolic regulation, including lipolysis inhibition in adipocytes and modulation of immune responses. The receptor is a potential target for treating metabolic disorders such as obesity and type 2 diabetes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Receptor activation inhibits lipolysis; altered signaling may contribute to adipocyte dysfunction. | PMID: 19033667 |
| Type 2 Diabetes | Lactate-mediated signaling via HYCC1 influences insulin sensitivity and glucose metabolism. | PMID: 23395176 |
| Inflammatory Disorders | HYCC1 modulates immune cell function; dysregulation linked to chronic inflammation. | PMID: 25646336 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose Tissue | 12.5 | Medium |
| Liver | 8.3 | Low |
| Skeletal Muscle | 6.7 | Low |
| Brain | 4.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Adipocytes | 15.0 | Primary human adipocytes |
| HepG2 | 7.1 | Hepatocellular carcinoma cell line |
| THP-1 | 5.3 | Monocytic leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | 0.01% | Reduced receptor activity in vitro |
| c.200G>A (p.Gly67Asp) | Missense | 0.005% | Altered ligand binding |
| c.350T>C (p.Leu117Pro) | Missense | 0.002% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Leu117Pro impair receptor signaling and lactate response.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • lactate binding |
| • adenylate cyclase inhibition | • negative regulation of lipolysis |
| • inflammatory response |
Pathways
• Lactate signaling via GPR81
• GPCR downstream signaling
• cAMP inhibition pathway
Protein Summary
HYCC1 encodes a 346-amino acid G protein-coupled receptor with seven transmembrane domains. It is activated by lactate and other hydroxycarboxylic acids, leading to inhibition of adenylate cyclase and reduced cAMP levels. The receptor is predominantly expressed in adipose tissue and liver, where it regulates lipolysis and metabolic homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HYCC1 Knockout HEK293 Cell Line | EDJ-KQ13049 | Human | 84668 | Details Get a Quote |
| HYCC1 Knockout A-549 Cell Line | EDJ-KQ43584 | Human | 84668 | Details Get a Quote |
| HYCC1 Knockout HCT 116 Cell Line | EDJ-KQ43585 | Human | 84668 | Details Get a Quote |
| HYCC1 Knockout HeLa Cell Line | EDJ-KQ43586 | Human | 84668 | Details Get a Quote |
