HUNK Gene: Hormonally Upregulated Neu-Associated Kinase
Comprehensive genomic and functional overview of HUNK, a serine/threonine kinase implicated in cancer and cellular signaling.
Gene Information Card
| Symbol | HUNK |
|---|---|
| Full Name | Hormonally Upregulated Neu-Associated Kinase |
| Gene Type | Protein coding |
| Chromosomal Location | 21q22.13 |
| NCBI Gene ID | 30811 ncbi.nlm.nih.gov/gene/30811 |
| Ensembl ID | ENSG00000142149 |
| UniProt ID | Q9H0B6 |
| OMIM ID | 608449 |
| HGNC ID | 13326 |
| Aliases | MAK-V, SNARK |
Description
HUNK (hormonally upregulated neu-associated kinase) encodes a serine/threonine protein kinase belonging to the AMPK-related kinase family. It is involved in cellular stress responses, autophagy, and tumorigenesis. HUNK is upregulated in response to hormonal signals and is implicated in breast cancer and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | HUNK overexpression promotes tumor cell survival and metastasis via phosphorylation of downstream targets. | PMID: 21502514; COSMIC |
| Colorectal Cancer | HUNK expression is elevated and associated with poor prognosis; may regulate autophagy. | PMID: 27323851; COSMIC |
| Ovarian Cancer | HUNK amplification and overexpression contribute to chemoresistance. | PMID: 25691885; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 5.2 | Medium |
| Colon | 3.8 | Low |
| Ovary | 4.1 | Low |
| Brain | 1.5 | Not detected |
| Liver | 2.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 6.5 | Hormone-responsive cell line |
| HCT116 (colorectal cancer) | 4.2 | High expression |
| HeLa (cervical cancer) | 3.0 | Moderate expression |
| A549 (lung cancer) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.02% | Unknown functional impact |
| c.1342G>A (p.Glu448Lys) | Missense | 0.01% | Predicted damaging (SIFT) |
| c.1576_1577insA (p.Thr526AsnfsTer2) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in HUNK are predicted to result in truncated, non-functional kinase domains.
Gain of Function (GOF)
Missense mutations in the kinase domain may enhance catalytic activity, though evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported for HUNK.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 - protein kinase activity | • GO:0005524 - ATP binding |
| • GO:0006468 - protein phosphorylation | • GO:0006914 - autophagy |
| • GO:0046777 - protein autophosphorylation |
Pathways
• AMPK signaling pathway (Reactome: R-HSA-163285)
• Autophagy (KEGG: hsa04140)
• mTOR signaling (Reactome: R-HSA-165159)
Protein Summary
HUNK is a 789-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory region. It is activated under energy stress and phosphorylates substrates involved in autophagy and cell survival. HUNK is overexpressed in several cancers and may serve as a therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| HUNK Knockout HEK293 Cell Line | EDJ-KQ13791 | Human | 30811 | Details Get a Quote |
| HUNK Knockout HeLa Cell Line | EDJ-KQ43583 | Human | 30811 | Details Get a Quote |
| HUNK Knockout SW480 Cell Line | EDJ-KZ287 | Human | 30811 | Details Get a Quote |
| HUNK Knockout A-549 Cell Line | EDJ-KQ64636 | Human | 30811 | Details Get a Quote |
| HUNK Knockout HCT 116 Cell Line | EDJ-KQ73086 | Human | 30811 | Details Get a Quote |
| HUNK Knockout HAP1 Cell Line | EDC07910 | Human | 30811 | Details Get a Quote |
Displaying Records 1 To 6 Of 6 Records
